82925-02-8Relevant articles and documents
ACETAMIDO-PHENYLBENZAMIDE DERIVATIVES AND METHODS OF USING THE SAME
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, (2022/04/09)
The present disclosure relates to compounds of Formula (I): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for the treatment of disorders in which expression of P-glycoprotein and/or cytochrome P450 (e.g., CYP3A4) is modulated (e.g., cancers which have developed multi-drug resistance).
Dimethoxy tetrahydroisoquinoline substituted purine derivative as well as preparation method and application thereof in anti-tumor drugs
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Paragraph 0030; 0034-0035, (2021/06/02)
The invention belongs to the technical field of medicines, and particularly relates to a dimethoxy tetrahydroisoquinoline substituted purine derivative and a preparation method thereof. The dimethoxy tetrahydroisoquinoline substituted purine derivative ca
Discovery of Encequidar, First-in-Class Intestine Specific P-glycoprotein Inhibitor
Smolinski, Michael P.,Urgaonkar, Sameer,Pitzonka, Laura,Cutler, Murray,Lee, GwanSun,Suh, Kwee Hyun,Lau, Johnson Y. N.
, p. 3677 - 3693 (2021/04/12)
Many chemotherapeutics, such as paclitaxel, are administered intravenously as they suffer from poor oral bioavailability, partly because of efflux mechanism of P-glycoprotein in the intestinal epithelium. To date, no drug has been approved by the U.S. Foo