(2R,3S,4R)-1-benzyloxy-4-tert-butyldimethylsilyloxy-2,3-O-isopropylidenedodec-6-ene-2,3-diol

Base Information

Chemical Name:(2R,3S,4R)-1-benzyloxy-4-tert-butyldimethylsilyloxy-2,3-O-isopropylidenedodec-6-ene-2,3-diol
CAS No.:145660-82-8
Molecular Formula:C₂₈H₄₈O₄Si
Molecular Weight:476.772
Hs Code.:

Synonyms:(2R,3S,4R)-1-benzyloxy-4-tert-butyldimethylsilyloxy-2,3-O-isopropylidenedodec-6-ene-2,3-diol

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Chemical Property of (2R,3S,4R)-1-benzyloxy-4-tert-butyldimethylsilyloxy-2,3-O-isopropylidenedodec-6-ene-2,3-diol

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Technology Process of (2R,3S,4R)-1-benzyloxy-4-tert-butyldimethylsilyloxy-2,3-O-isopropylidenedodec-6-ene-2,3-diol

There total 5 articles about (2R,3S,4R)-1-benzyloxy-4-tert-butyldimethylsilyloxy-2,3-O-isopropylidenedodec-6-ene-2,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 145660-81-7
(2R,3S,4R)-1-benzyloxy-4-tert-butyldimethylsilyloxy-2,3-O-isopropylidenedodec-6-yne-2,3-diol

: 145660-82-8
(2R,3S,4R)-1-benzyloxy-4-tert-butyldimethylsilyloxy-2,3-O-isopropylidenedodec-6-ene-2,3-diol

Guidance literature:: With quinoline; hydrogen; Pd-Pb-CaCO₃ (Lindlar catalyst); In hexane; under 760 Torr;
DOI:10.1039/P19920002705

Reference yield:

: 110-53-2
1-Bromopentane

: 145660-82-8
(2R,3S,4R)-1-benzyloxy-4-tert-butyldimethylsilyloxy-2,3-O-isopropylidenedodec-6-ene-2,3-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 1) BuLi / 1) THF, hexane, -40 deg C, 20 min, 2) HMPA, a) -10 deg C, 1 h, b) 15 deg C, overnight

2: 99 percent / H₂, quinoline / Pd-Pb-CaCO₃ / hexane / 760 Torr

With quinoline; n-butyllithium; hydrogen; Pd-Pb-CaCO₃ (Lindlar catalyst); In hexane;
DOI:10.1039/P19920002705

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 145660-82-8
(2R,3S,4R)-1-benzyloxy-4-tert-butyldimethylsilyloxy-2,3-O-isopropylidenedodec-6-ene-2,3-diol

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / imidazole / dimethylformamide / Ambient temperature

2: 1) BuLi / 1) THF, hexane, -40 deg C, 20 min, 2) HMPA, a) -10 deg C, 1 h, b) 15 deg C, overnight

3: 99 percent / H₂, quinoline / Pd-Pb-CaCO₃ / hexane / 760 Torr

With 1H-imidazole; quinoline; n-butyllithium; hydrogen; Pd-Pb-CaCO₃ (Lindlar catalyst); In hexane; N,N-dimethyl-formamide;
DOI:10.1039/P19920002705