4,4-difluoro-1-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)cyclohexanol

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Chemical Name:4,4-difluoro-1-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)cyclohexanol
CAS No.:1224948-68-8
Molecular Formula:C₂₃H₂₄F₂N₂O₂
Molecular Weight:398.453
Hs Code.:

Synonyms:4,4-difluoro-1-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)cyclohexanol

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Chemical Property of 4,4-difluoro-1-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)cyclohexanol

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Technology Process of 4,4-difluoro-1-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)cyclohexanol

There total 12 articles about 4,4-difluoro-1-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1224950-02-0
1-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-4-oxo-cyclohexan-1-yl acetate

: 1224948-68-8
4,4-difluoro-1-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)cyclohexanol

Guidance literature:: 1-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)-4-oxo-cyclohexan-1-yl acetate; With dimethylaminosulphur trifluoride; In dichloromethane; at 20 ℃; for 2h;

With sodium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 6h;

Reference yield:

: C₂₅H₂₆F₂N₂O₃

: 1224948-68-8
4,4-difluoro-1-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)cyclohexanol

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 6h;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1224948-68-8
4,4-difluoro-1-(1-(4-methoxyphenyl)-5-(p-tolyl)-1H-pyrazol-3-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 12 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -76 °C

1.2: 2 h / -74 °C

2.1: potassium carbonate; methanol / 2 h / 20 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / 0.92 h / -72 °C

3.2: 0.58 h / -72 °C

4.1: manganese(IV) oxide / dichloromethane / 15 h / 20 °C

5.1: triethylamine / ethanol / 0.5 h / 20 °C

5.2: 15 h / 20 °C

6.1: hydrogenchloride; water / tetrahydrofuran / 15 h / 20 °C

6.2: 0 °C

7.1: sodium tetrahydroborate; methanol / 2 h / 20 °C

8.1: dmap; pyridine / dichloromethane / 66 h / 20 °C

9.1: potassium carbonate; methanol / 4 h / 20 °C

10.1: Dess-Martin periodane / dichloromethane / 2 h / 0 °C

11.1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / 20 °C

12.1: sodium hydroxide; water / tetrahydrofuran; methanol / 6 h / 20 °C

With pyridine; hydrogenchloride; methanol; dmap; manganese(IV) oxide; sodium tetrahydroborate; n-butyllithium; diethylamino-sulfur trifluoride; water; potassium carbonate; Dess-Martin periodane; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane;