tert-butyl 4-(4-fluorophenylcarbamoyl)piperidine-1-carboxylic acid ester

Base Information

Chemical Name:tert-butyl 4-(4-fluorophenylcarbamoyl)piperidine-1-carboxylic acid ester
CAS No.:503149-31-3
Molecular Formula:C₁₇H₂₃FN₂O₃
Molecular Weight:322.38
Hs Code.:

Synonyms:tert-butyl 4-(4-fluorophenylcarbamoyl)piperidine-1-carboxylic acid ester

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Chemical Property of tert-butyl 4-(4-fluorophenylcarbamoyl)piperidine-1-carboxylic acid ester

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Technology Process of tert-butyl 4-(4-fluorophenylcarbamoyl)piperidine-1-carboxylic acid ester

There total 4 articles about tert-butyl 4-(4-fluorophenylcarbamoyl)piperidine-1-carboxylic acid ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 371-40-4
4-fluoroaniline

: 503149-31-3
tert-butyl 4-(4-fluorophenylcarbamoyl)piperidine-1-carboxylic acid ester

Guidance literature:: N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid; With pyridine; thionyl chloride; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

4-fluoroaniline; With triethylamine; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1016/j.ejmech.2018.12.064

Reference yield: 75.0%

: 503149-31-3
tert-butyl 4-(4-fluorophenylcarbamoyl)piperidine-1-carboxylic acid ester

Guidance literature:: With pyridine; thionyl chloride; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

With triethylamine; In dichloromethane; at 20 ℃; for 6h;