1-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-methylphenyl}-3-isoxazol-3-ylurea

Base Information

Chemical Name:1-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-methylphenyl}-3-isoxazol-3-ylurea
CAS No.:1448985-32-7
Molecular Formula:C₂₇H₃₃N₇O₅
Molecular Weight:535.603
Hs Code.:

1-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-methylphenyl}-3-isoxazol-3-ylurea

Synonyms:1-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-methylphenyl}-3-isoxazol-3-ylurea

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Chemical Property of 1-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-methylphenyl}-3-isoxazol-3-ylurea

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Technology Process of 1-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-methylphenyl}-3-isoxazol-3-ylurea

There total 11 articles about 1-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-methylphenyl}-3-isoxazol-3-ylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1750-42-1
3-aminoisoxazole

: 32315-10-9
bis(trichloromethyl) carbonate

: 1448988-16-6
4-(4-amino-3-methylphenyl)-6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

: 1448985-32-7
1-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-methylphenyl}-3-isoxazol-3-ylurea

Guidance literature:: bis(trichloromethyl) carbonate; 4-(4-amino-3-methylphenyl)-6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one; With triethylamine; In dichloromethane; at 20 ℃; for 0.75h; Inert atmosphere;

3-aminoisoxazole; In dichloromethane; at 20 ℃;

Reference yield:

: 1448987-72-1
4-chloro-6-ethyl-8,8-dimethyl-2-methylsulfanyl-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

: 1448985-32-7
1-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-methylphenyl}-3-isoxazol-3-ylurea

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 4 °C

1.2: 2 h / 4 °C

2.1: magnesium bis(monoperoxyphthalate)hexahydrate / acetonitrile; ethanol / 2 h / 20 °C

3.1: triethylamine / dimethyl sulfoxide / 0.5 h / 100 °C / Microwave irradiation

4.1: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 25 °C / 2068.65 Torr

5.1: triethylamine / dichloromethane / 3 h / 4 °C

6.1: potassium phosphate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 0.5 h / 100 °C / Microwave irradiation

7.1: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

8.1: triethylamine / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

8.2: 20 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; magnesium bis(monoperoxyphthalate)hexahydrate; palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1448988-15-5
{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-methylphenyl}carbamic acid tert-butyl ester

: 1448985-32-7
1-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-methylphenyl}-3-isoxazol-3-ylurea

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

2.1: triethylamine / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

2.2: 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane;