{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-methylphenyl}carbamic acid tert-butyl ester

Base Information

Chemical Name:{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-methylphenyl}carbamic acid tert-butyl ester
CAS No.:1448988-15-5
Molecular Formula:C₂₈H₃₉N₅O₅
Molecular Weight:525.648
Hs Code.:

{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-methylphenyl}carbamic acid tert-butyl ester

Synonyms:{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-methylphenyl}carbamic acid tert-butyl ester

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Chemical Property of {4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-methylphenyl}carbamic acid tert-butyl ester

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Technology Process of {4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-methylphenyl}carbamic acid tert-butyl ester

There total 9 articles about {4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-methylphenyl}carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 508223-54-9
[2-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]carbamic acid tert-butyl ester

: 1448987-83-4
trifluoromethanesulfonic acid 6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl ester

: 1448988-15-5
{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-methylphenyl}carbamic acid tert-butyl ester

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; In 1,4-dioxane; water; at 100 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1448987-72-1
4-chloro-6-ethyl-8,8-dimethyl-2-methylsulfanyl-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

: 1448988-15-5
{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-methylphenyl}carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 4 °C

1.2: 2 h / 4 °C

2.1: magnesium bis(monoperoxyphthalate)hexahydrate / acetonitrile; ethanol / 2 h / 20 °C

3.1: triethylamine / dimethyl sulfoxide / 0.5 h / 100 °C / Microwave irradiation

4.1: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 25 °C / 2068.65 Torr

5.1: triethylamine / dichloromethane / 3 h / 4 °C

6.1: potassium phosphate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 0.5 h / 100 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; magnesium bis(monoperoxyphthalate)hexahydrate; palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1448987-80-1
4-benzyloxy-6-ethyl-2-methanesulfonyl-8,8-dimethyl-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

: 1448988-15-5
{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-methylphenyl}carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dimethyl sulfoxide / 0.5 h / 100 °C / Microwave irradiation

2: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 25 °C / 2068.65 Torr

3: triethylamine / dichloromethane / 3 h / 4 °C

4: potassium phosphate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 0.5 h / 100 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; palladium 10% on activated carbon; hydrogen; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide;