4-(4-amino-3-methylphenyl)-6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

Base Information

Chemical Name:4-(4-amino-3-methylphenyl)-6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one
CAS No.:1448988-16-6
Molecular Formula:C₂₃H₃₁N₅O₃
Molecular Weight:425.531
Hs Code.:

Synonyms:4-(4-amino-3-methylphenyl)-6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

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Chemical Property of 4-(4-amino-3-methylphenyl)-6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

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Technology Process of 4-(4-amino-3-methylphenyl)-6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

There total 10 articles about 4-(4-amino-3-methylphenyl)-6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1448988-15-5
{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-2-methylphenyl}carbamic acid tert-butyl ester

: 1448988-16-6
4-(4-amino-3-methylphenyl)-6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.75h;

Reference yield:

: 1448987-72-1
4-chloro-6-ethyl-8,8-dimethyl-2-methylsulfanyl-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

: 1448988-16-6
4-(4-amino-3-methylphenyl)-6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 4 °C

1.2: 2 h / 4 °C

2.1: magnesium bis(monoperoxyphthalate)hexahydrate / acetonitrile; ethanol / 2 h / 20 °C

3.1: triethylamine / dimethyl sulfoxide / 0.5 h / 100 °C / Microwave irradiation

4.1: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 25 °C / 2068.65 Torr

5.1: triethylamine / dichloromethane / 3 h / 4 °C

6.1: potassium phosphate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 0.5 h / 100 °C / Microwave irradiation

7.1: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; magnesium bis(monoperoxyphthalate)hexahydrate; palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1448987-80-1
4-benzyloxy-6-ethyl-2-methanesulfonyl-8,8-dimethyl-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

: 1448988-16-6
4-(4-amino-3-methylphenyl)-6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-7,8-dihydro-6H-9-oxa-1,3,6-triazabenzocyclohepten-5-one

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dimethyl sulfoxide / 0.5 h / 100 °C / Microwave irradiation

2: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 25 °C / 2068.65 Torr

3: triethylamine / dichloromethane / 3 h / 4 °C

4: potassium phosphate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 0.5 h / 100 °C / Microwave irradiation

5: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; palladium 10% on activated carbon; hydrogen; triethylamine; trifluoroacetic acid; In 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide;