(2-BENZHYDRYLOXYCARBONYLAMINO-6-OXO-1,6-DIHYDRO-PURIN-9-YL)-ACETIC ACID

Base Information

• Chemical Name: (2-BENZHYDRYLOXYCARBONYLAMINO-6-OXO-1,6-DIHYDRO-PURIN-9-YL)-ACETIC ACID
• CAS No.: 169287-79-0
• Molecular Formula: C21H17 N5 O5
• Molecular Weight: 419.396
• Hs Code.: 2933990090
• Mol file: 169287-79-0.mol

Synonyms:(2-BENZHYDRYLOXYCARBONYLAMINO-6-OXO-1,6-DIHYDRO-PURIN-9-YL)-ACETIC ACID ;(2-Benzhydryloxycarbonylamino-6-oxo-1,6-dihydro-

Chemical Property of (2-BENZHYDRYLOXYCARBONYLAMINO-6-OXO-1,6-DIHYDRO-PURIN-9-YL)-ACETIC ACID

Chemical Property:

• Refractive Index: 1.711
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 139.20000
• Density: 1.48g/cm³
• LogP: 2.61530

Purity/Quality:

99% ^*data from raw suppliers

2-(2-(((Benzhydryloxy)carbonyl)amino)-6-oxo-1H-purin-9(6H)-yl)aceticacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-BENZHYDRYLOXYCARBONYLAMINO-6-OXO-1,6-DIHYDRO-PURIN-9-YL)-ACETIC ACID

There total 4 articles about (2-BENZHYDRYLOXYCARBONYLAMINO-6-OXO-1,6-DIHYDRO-PURIN-9-YL)-ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-Diphenylmethanol (91-01-0) → 2-(2-(benzhydryloxycarbonylamino)-guanin-9-yl)acetic acid (169287-79-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diisopropylethylamine / tetrahydrofuran / 0.5 h / 0 °C

1.2: 63.8 percent / tetrahydrofuran / 12 h / 0 - 20 °C

2.1: 86.5 percent / sodium hydride; 3-hydroxypropionitrile / tetrahydrofuran / -78 - 20 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; 3-Hydroxypropionitrile; In tetrahydrofuran;

DOI:10.1021/ol0358408

Reference yield:

2-amino-6-chloropurine (10310-21-1) → 2-(2-(benzhydryloxycarbonylamino)-guanin-9-yl)acetic acid (169287-79-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 67.7 percent / potassium carbonate / dimethylformamide / 0 - 20 °C

2.1: diisopropylethylamine / tetrahydrofuran / 0.5 h / 0 °C

2.2: 63.8 percent / tetrahydrofuran / 12 h / 0 - 20 °C

3.1: 86.5 percent / sodium hydride; 3-hydroxypropionitrile / tetrahydrofuran / -78 - 20 °C

With sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-Hydroxypropionitrile; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ol0358408

Reference yield:

benzyl 2-amino-6-chloropurine-9-acetate (169287-67-6) → 2-(2-(benzhydryloxycarbonylamino)-guanin-9-yl)acetic acid (169287-79-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diisopropylethylamine / tetrahydrofuran / 0.5 h / 0 °C

1.2: 63.8 percent / tetrahydrofuran / 12 h / 0 - 20 °C

2.1: 86.5 percent / sodium hydride; 3-hydroxypropionitrile / tetrahydrofuran / -78 - 20 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; 3-Hydroxypropionitrile; In tetrahydrofuran;

DOI:10.1021/ol0358408

upstream raw materials:

1,1-Diphenylmethanol

2-amino-6-chloropurine

benzyl 2-amino-6-chloropurine-9-acetate

Downstream raw materials:

(S)-allyl 2-(N-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-(tert-butoxycarbonylamino)hexyl)-2-(2-(benzhydryloxycarbonylamino)-guanin-9-yl)acetamido)acetate

N-[2-(benzothiazole-2-sulfonylamino)-ethyl]-N-{[2-N-(benzhydryloxycarbonyl)-guanin-9-yl]-acetyl}-glycine ethyl ester

benzyl N-(2-azidoethyl)-N-[2-N-(benzhydryloxycarbonyl)guanine-9-acetyl]glycinate

Refernces

• 1、 -. "PNA monomer and precursor". . . Retrieved 2008/06/13.