(3R,5S)-(3,5-dimethyl-piperazin-1-yl)-(1-m-tolyl-1H-[1,2,4]triazol-3-yl)-methanone

Base Information

Chemical Name:(3R*,5S*)-(3,5-dimethyl-piperazin-1-yl)-(1-m-tolyl-1H-[1,2,4]triazol-3-yl)-methanone
CAS No.:1443760-14-2
Molecular Formula:C₁₆H₂₁N₅O
Molecular Weight:299.376
Hs Code.:

Synonyms:(3R*,5S*)-(3,5-dimethyl-piperazin-1-yl)-(1-m-tolyl-1H-[1,2,4]triazol-3-yl)-methanone

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Chemical Property of (3R*,5S*)-(3,5-dimethyl-piperazin-1-yl)-(1-m-tolyl-1H-[1,2,4]triazol-3-yl)-methanone

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Technology Process of (3R*,5S*)-(3,5-dimethyl-piperazin-1-yl)-(1-m-tolyl-1H-[1,2,4]triazol-3-yl)-methanone

There total 3 articles about (3R*,5S*)-(3,5-dimethyl-piperazin-1-yl)-(1-m-tolyl-1H-[1,2,4]triazol-3-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1245649-64-2
1-m-tolyl-1H-[1,2,4]-triazole-3-carboxylic acid

: 21655-48-1,1013625-96-1
cis-2,6-dimethylpiperazine

: 1443760-14-2
(3R*,5S*)-(3,5-dimethyl-piperazin-1-yl)-(1-m-tolyl-1H-[1,2,4]triazol-3-yl)-methanone

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield: 58.0%

: cis-2,6-dimethylpiperazine

: 1245649-64-2
1-m-tolyl-1H-[1,2,4]-triazole-3-carboxylic acid

: 1443760-14-2
(3R*,5S*)-(3,5-dimethyl-piperazin-1-yl)-(1-m-tolyl-1H-[1,2,4]triazol-3-yl)-methanone

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 108-44-1
1-amino-3-methylbenzene

: 1443760-14-2
(3R*,5S*)-(3,5-dimethyl-piperazin-1-yl)-(1-m-tolyl-1H-[1,2,4]triazol-3-yl)-methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium nitrite; tetrafluoroboric acid / water / 0 - 20 °C

1.2: 20 °C / Cooling with ice

1.3: 3 h

2.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 12 h / 20 °C

With tetrafluoroboric acid; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium nitrite; In water; N,N-dimethyl-formamide;