Succinic acid mono-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-methoxy-ethoxy)-5-(5-methyl-4-oxo-2-thioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

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Chemical Name:Succinic acid mono-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-methoxy-ethoxy)-5-(5-methyl-4-oxo-2-thioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester
CAS No.:607353-04-8
Molecular Formula:C₃₈H₄₂N₂O₁₁S
Molecular Weight:734.824
Hs Code.:

Succinic acid mono-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-methoxy-ethoxy)-5-(5-methyl-4-oxo-2-thioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

Synonyms:Succinic acid mono-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-methoxy-ethoxy)-5-(5-methyl-4-oxo-2-thioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

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Chemical Property of Succinic acid mono-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-methoxy-ethoxy)-5-(5-methyl-4-oxo-2-thioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

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Technology Process of Succinic acid mono-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-methoxy-ethoxy)-5-(5-methyl-4-oxo-2-thioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

There total 8 articles about Succinic acid mono-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-methoxy-ethoxy)-5-(5-methyl-4-oxo-2-thioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 108-30-5
succinic acid anhydride

: 607352-97-6
1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-5-methyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

: 607353-04-8
Succinic acid mono-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-methoxy-ethoxy)-5-(5-methyl-4-oxo-2-thioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

Guidance literature:: With dmap; In 1,2-dichloro-ethane; at 20 ℃; for 18h;
DOI:10.1021/ol0348607

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 607353-04-8
Succinic acid mono-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-methoxy-ethoxy)-5-(5-methyl-4-oxo-2-thioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90.33 percent / DMAP; pyridine / 4 h / 20 °C

2: 66.2 percent / 1,1,3,3-tetramethylguanidine; hydrogen sulfide / pyridine / 72 h / 20 °C

3: 100 percent / DMAP / 1,2-dichloro-ethane / 18 h / 20 °C

With pyridine; dmap; hydrogen sulfide; N,N,N',N'-tetramethylguanidine; In pyridine; 1,2-dichloro-ethane;
DOI:10.1021/ol0348607

Reference yield:

: 163759-50-0
5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(2-methoxyethyl)-5-methyluridine

: 607353-04-8
Succinic acid mono-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-methoxy-ethoxy)-5-(5-methyl-4-oxo-2-thioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / DMAP; pyridine

2: AcOH; H₂O / 20 °C

3: 19.6 g / pyridine / CH₂Cl₂ / 2 h / -20 °C

4: 75.4 percent / NaHCO₃ / 36 h / Heating

5: 90.33 percent / DMAP; pyridine / 4 h / 20 °C

6: 66.2 percent / 1,1,3,3-tetramethylguanidine; hydrogen sulfide / pyridine / 72 h / 20 °C

7: 100 percent / DMAP / 1,2-dichloro-ethane / 18 h / 20 °C

With pyridine; dmap; hydrogen sulfide; water; sodium hydrogencarbonate; acetic acid; N,N,N',N'-tetramethylguanidine; In pyridine; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ol0348607