benzyl 2-(2-(tert-butoxycarbonylamino)-2-methylpropanoyl)-1-phenylhydrazinecarboxylate

Base Information

Chemical Name:benzyl 2-(2-(tert-butoxycarbonylamino)-2-methylpropanoyl)-1-phenylhydrazinecarboxylate
CAS No.:1361235-77-9
Molecular Formula:C₂₃H₂₉N₃O₅
Molecular Weight:427.5
Hs Code.:

Synonyms:benzyl 2-(2-(tert-butoxycarbonylamino)-2-methylpropanoyl)-1-phenylhydrazinecarboxylate

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Chemical Property of benzyl 2-(2-(tert-butoxycarbonylamino)-2-methylpropanoyl)-1-phenylhydrazinecarboxylate

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Technology Process of benzyl 2-(2-(tert-butoxycarbonylamino)-2-methylpropanoyl)-1-phenylhydrazinecarboxylate

There total 3 articles about benzyl 2-(2-(tert-butoxycarbonylamino)-2-methylpropanoyl)-1-phenylhydrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1361235-75-7
tert-butyl 2-methyl-1-oxo-1-(2-phenylhydrazinyl)propan-2-ylcarbamate

: 501-53-1,94274-21-2
benzyl chloroformate

: 1361235-77-9
benzyl 2-(2-(tert-butoxycarbonylamino)-2-methylpropanoyl)-1-phenylhydrazinecarboxylate

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm201331s

Reference yield:

: 30992-29-1
Boc-Aib-OH

: 1361235-77-9
benzyl 2-(2-(tert-butoxycarbonylamino)-2-methylpropanoyl)-1-phenylhydrazinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

2: sodium hydroxide / tetrahydrofuran; water / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm201331s

Reference yield:

: 100-63-0
phenylhydrazine

: 1361235-77-9
benzyl 2-(2-(tert-butoxycarbonylamino)-2-methylpropanoyl)-1-phenylhydrazinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

2: sodium hydroxide / tetrahydrofuran; water / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm201331s