6-(4-Azido-benzenesulfonylamino)-2-(3-pyridin-3-yl-propyl)-hexanoic acid ethyl ester

Base Information

Chemical Name:6-(4-Azido-benzenesulfonylamino)-2-(3-pyridin-3-yl-propyl)-hexanoic acid ethyl ester
CAS No.:1026168-68-2
Molecular Formula:C₂₂H₂₉N₅O₄S
Molecular Weight:459.569
Hs Code.:

Synonyms:6-(4-Azido-benzenesulfonylamino)-2-(3-pyridin-3-yl-propyl)-hexanoic acid ethyl ester

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Chemical Property of 6-(4-Azido-benzenesulfonylamino)-2-(3-pyridin-3-yl-propyl)-hexanoic acid ethyl ester

Chemical Property:

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Technology Process of 6-(4-Azido-benzenesulfonylamino)-2-(3-pyridin-3-yl-propyl)-hexanoic acid ethyl ester

There total 7 articles about 6-(4-Azido-benzenesulfonylamino)-2-(3-pyridin-3-yl-propyl)-hexanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 41038-63-5
3-(pyridin-3-yl)propyl bromide hydrobromide

: 1026168-68-2
6-(4-Azido-benzenesulfonylamino)-2-(3-pyridin-3-yl-propyl)-hexanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) Na / 1.) EtOH, 2.) EtOH, reflux, 10 h

2: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, 60 deg C, 10 h

3: NaN₃, NaI, 18-crown-6 / dimethylformamide / 18 h / 60 °C

4: Ph₃P, H₂O / tetrahydrofuran / 62 h / Ambient temperature

5: 6N HCl / acetic acid / 18 h / Heating

6: SOCl₂ / 18 h / Heating

7: Et₃N / CH₂Cl₂ / 18 h

With hydrogenchloride; thionyl chloride; sodium azide; 18-crown-6 ether; water; sodium; sodium hydride; triethylamine; triphenylphosphine; sodium iodide; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00101a015

Reference yield:

: 144385-78-4
6-Amino-2-(3-pyridin-3-yl-propyl)-hexanoic acid

: 1026168-68-2
6-(4-Azido-benzenesulfonylamino)-2-(3-pyridin-3-yl-propyl)-hexanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / 18 h / Heating

2: Et₃N / CH₂Cl₂ / 18 h

With thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1021/jm00101a015

Reference yield:

: 84200-02-2
diethyl [3-(pyridin-3-yl)-propyl]-malonate

: 1026168-68-2
6-(4-Azido-benzenesulfonylamino)-2-(3-pyridin-3-yl-propyl)-hexanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, 60 deg C, 10 h

2: NaN₃, NaI, 18-crown-6 / dimethylformamide / 18 h / 60 °C

3: Ph₃P, H₂O / tetrahydrofuran / 62 h / Ambient temperature

4: 6N HCl / acetic acid / 18 h / Heating

5: SOCl₂ / 18 h / Heating

6: Et₃N / CH₂Cl₂ / 18 h

With hydrogenchloride; thionyl chloride; sodium azide; 18-crown-6 ether; water; sodium hydride; triethylamine; triphenylphosphine; sodium iodide; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00101a015