5'-(7-ethyl-7H-imidazo[4,5-c]pyridazin-4-yl)-4-(ethylsulfonyl)-2'-fluoro-[1,1'-biphenyl]-2-carbonitrile

Base Information

Chemical Name:5'-(7-ethyl-7H-imidazo[4,5-c]pyridazin-4-yl)-4-(ethylsulfonyl)-2'-fluoro-[1,1'-biphenyl]-2-carbonitrile
CAS No.:1614245-77-0
Molecular Formula:C₂₂H₁₈FN₅O₂S
Molecular Weight:435.482
Hs Code.:

Synonyms:5'-(7-ethyl-7H-imidazo[4,5-c]pyridazin-4-yl)-4-(ethylsulfonyl)-2'-fluoro-[1,1'-biphenyl]-2-carbonitrile

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Chemical Property of 5'-(7-ethyl-7H-imidazo[4,5-c]pyridazin-4-yl)-4-(ethylsulfonyl)-2'-fluoro-[1,1'-biphenyl]-2-carbonitrile

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Technology Process of 5'-(7-ethyl-7H-imidazo[4,5-c]pyridazin-4-yl)-4-(ethylsulfonyl)-2'-fluoro-[1,1'-biphenyl]-2-carbonitrile

There total 14 articles about 5'-(7-ethyl-7H-imidazo[4,5-c]pyridazin-4-yl)-4-(ethylsulfonyl)-2'-fluoro-[1,1'-biphenyl]-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1268521-56-7
4-chloro-7-ethyl-7H-imidazo[4,5-c]pyridazine

: 1614246-82-0
4-(ethylsulfonyl)-2'-fluoro-5'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1-biphenyl]-2-carbonitrile

: 1614245-77-0
5'-(7-ethyl-7H-imidazo[4,5-c]pyridazin-4-yl)-4-(ethylsulfonyl)-2'-fluoro-[1,1'-biphenyl]-2-carbonitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; at 20 - 90 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 1614246-24-0
5-chloro-N³-ethylpyridazine-3,4-diamine

: 1614245-77-0
5'-(7-ethyl-7H-imidazo[4,5-c]pyridazin-4-yl)-4-(ethylsulfonyl)-2'-fluoro-[1,1'-biphenyl]-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 4 h / Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water / 1.5 h / 20 - 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water;

Reference yield:

: 88-65-3
2-bromobenzoic-acid

: 1614245-77-0
5'-(7-ethyl-7H-imidazo[4,5-c]pyridazin-4-yl)-4-(ethylsulfonyl)-2'-fluoro-[1,1'-biphenyl]-2-carbonitrile

Guidance literature:: Multi-step reaction with 10 steps

1: chlorosulfonic acid / 16.66 h / Reflux

2: hydrazine hydrate / tetrahydrofuran / 0 - 20 °C

3: sodium acetate / 20 h / Reflux

4: 1,1'-carbonyldiimidazole; ammonia / tetrahydrofuran / 0.75 h / 22 - 41 °C / Inert atmosphere

5: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 16 h / Inert atmosphere

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 12 h / 110 °C / Inert atmosphere

7: trifluoroacetic acid / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

8: dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere

9: potassium acetate; [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II)-acetone complex / 1,4-dioxane

10: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water / 1.5 h / 20 - 90 °C / Inert atmosphere

With chlorosulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II)-acetone complex; ammonia; potassium acetate; sodium acetate; sodium carbonate; hydrazine hydrate; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;