4-(ethylsulfonyl)-2'-fluoro-5'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1-biphenyl]-2-carbonitrile

Base Information

Chemical Name:4-(ethylsulfonyl)-2'-fluoro-5'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1-biphenyl]-2-carbonitrile
CAS No.:1614246-82-0
Molecular Formula:C₂₁H₂₃BFNO₄S
Molecular Weight:415.293
Hs Code.:

Synonyms:4-(ethylsulfonyl)-2'-fluoro-5'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1-biphenyl]-2-carbonitrile

Suppliers and Price of 4-(ethylsulfonyl)-2'-fluoro-5'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1-biphenyl]-2-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(ethylsulfonyl)-2'-fluoro-5'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1-biphenyl]-2-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(ethylsulfonyl)-2'-fluoro-5'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1-biphenyl]-2-carbonitrile

There total 12 articles about 4-(ethylsulfonyl)-2'-fluoro-5'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1-biphenyl]-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1614246-81-9
2'-cyano-4'-(ethylsulfonyl)-6-fluoro[1,1'-biphenyl]-3-yl trifluoromethanesulfonate

: 73183-34-3
bis(pinacol)diborane

: 1614246-82-0
4-(ethylsulfonyl)-2'-fluoro-5'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1-biphenyl]-2-carbonitrile

Guidance literature:: With [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II)-acetone complex; potassium acetate; In 1,4-dioxane;

Reference yield:

: 88-65-3
2-bromobenzoic-acid

: 1614246-82-0
4-(ethylsulfonyl)-2'-fluoro-5'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1-biphenyl]-2-carbonitrile

Guidance literature:: Multi-step reaction with 9 steps

1: chlorosulfonic acid / 16.66 h / Reflux

2: hydrazine hydrate / tetrahydrofuran / 0 - 20 °C

3: sodium acetate / 20 h / Reflux

4: 1,1'-carbonyldiimidazole; ammonia / tetrahydrofuran / 0.75 h / 22 - 41 °C / Inert atmosphere

5: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 16 h / Inert atmosphere

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 12 h / 110 °C / Inert atmosphere

7: trifluoroacetic acid / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

8: dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere

9: potassium acetate; [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II)-acetone complex / 1,4-dioxane

With chlorosulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II)-acetone complex; ammonia; potassium acetate; sodium acetate; sodium carbonate; hydrazine hydrate; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 3285-31-2
2-bromo-5-(chlorosulfonyl)benzoic acid

: 1614246-82-0
4-(ethylsulfonyl)-2'-fluoro-5'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1-biphenyl]-2-carbonitrile

Guidance literature:: Multi-step reaction with 8 steps

1: hydrazine hydrate / tetrahydrofuran / 0 - 20 °C

2: sodium acetate / 20 h / Reflux

3: 1,1'-carbonyldiimidazole; ammonia / tetrahydrofuran / 0.75 h / 22 - 41 °C / Inert atmosphere

4: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 16 h / Inert atmosphere

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 12 h / 110 °C / Inert atmosphere

6: trifluoroacetic acid / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

7: dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere

8: potassium acetate; [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II)-acetone complex / 1,4-dioxane

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II)-acetone complex; ammonia; potassium acetate; sodium acetate; sodium carbonate; hydrazine hydrate; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;