ethyl 3-(3,4-dichlorophenyl)propiolate

Base Information

• Chemical Name: ethyl 3-(3,4-dichlorophenyl)propiolate
• CAS No.: 91183-45-8
• Molecular Formula: C₁₁H₈Cl₂O₂
• Molecular Weight: 243.089
• Mol file: 91183-45-8.mol

Synonyms:ethyl 3-(3,4-dichlorophenyl)propiolate

Chemical Property of ethyl 3-(3,4-dichlorophenyl)propiolate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-(3,4-dichlorophenyl)propiolate

There total 2 articles about ethyl 3-(3,4-dichlorophenyl)propiolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3,4-dichloroiodobenzene (20555-91-3) + propynoic acid ethyl ester (623-47-2) → ethyl 3-(3,4-dichlorophenyl)propiolate (91183-45-8)

Guidance literature:

3,4-dichloroiodobenzene; With copper(l) iodide; caesium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 20 ℃; for 0.0833333h; Inert atmosphere;

propynoic acid ethyl ester; In tetrahydrofuran; at 35 ℃; Inert atmosphere;

Reference yield:

→ ethyl 3-(3,4-dichlorophenyl)propiolate (91183-45-8)

Guidance literature:

3,4-Dichlor-phenylpropiolsaeure, abs. A., HCl od. H2SO4;

DOI:10.1021/jo01066a608

Reference yield: 83.0%

ethyl 3-(3,4-dichlorophenyl)propiolate (91183-45-8) + N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine (93102-05-7) → 1-benzyl-4-(3,4-dichloro-phenyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid (1229236-33-2)

Guidance literature:

ethyl 3-(3,4-dichlorophenyl)propiolate; N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine; With trifluoroacetic acid; In dichloromethane; at 20 - 25 ℃; for 3h;

With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 20h;

With hydrogenchloride; In water; pH=2.5;

upstream raw materials:

3,4-dichloroiodobenzene

propynoic acid ethyl ester

Downstream raw materials:

(Z)-5-(3,4-dichlorobenzylidene)-3-(furan-2-ylmethyl)-2-thioxo-thiazolidin-4-one

(E)-3-(3,4-dichlorophenyl)-2-cyanoacrylic acid ethyl ester

1-benzyl-4-(3,4-dichloro-phenyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid