2-benzyl-3-(4-methoxyphenyl)benzofuran

Base Information

• Chemical Name: 2-benzyl-3-(4-methoxyphenyl)benzofuran
• CAS No.: 1404300-85-1
• Molecular Formula: C₂₂H₁₈O₂
• Molecular Weight: 314.384
• Mol file: 1404300-85-1.mol

Synonyms:2-benzyl-3-(4-methoxyphenyl)benzofuran

Chemical Property of 2-benzyl-3-(4-methoxyphenyl)benzofuran

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-benzyl-3-(4-methoxyphenyl)benzofuran

There total 5 articles about 2-benzyl-3-(4-methoxyphenyl)benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methoxybenzene (100-66-3) + 1-[2-(tert-butyldimethylsilyloxy)phenyl]-3-phenylprop-2-yn-1-ol (642089-49-4) → 2-benzyl-3-(4-methoxyphenyl)benzofuran (1404300-85-1)

Guidance literature:

methoxybenzene; 1-[2-(tert-butyldimethylsilyloxy)phenyl]-3-phenylprop-2-yn-1-ol; With boron trifluoride diethyl etherate; In acetonitrile; at 20 ℃; Inert atmosphere;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; acetonitrile; at 20 ℃; for 12h; Inert atmosphere; Reflux;

DOI:10.1002/ejoc.201200708

Reference yield:

2-(1-(4-methoxyphenyl)-3-phenylprop-2-yn-1-yl)phenol → 2-benzyl-3-(4-methoxyphenyl)benzofuran (1404300-85-1)

Guidance literature:

With potassium tert-butylate; In 1,4-dioxane; at 20 ℃;

DOI:10.1055/s-0039-1691739

Reference yield:

2-((tert-butyldimethylsilyl)oxy)benzaldehyde (116585-12-7) → 2-benzyl-3-(4-methoxyphenyl)benzofuran (1404300-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere

1.2: 4 h / -78 °C / Inert atmosphere

2.1: boron trifluoride diethyl etherate / acetonitrile / 20 °C / Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere; Reflux

With n-butyllithium; boron trifluoride diethyl etherate; In tetrahydrofuran; acetonitrile;

DOI:10.1002/ejoc.201200708

upstream raw materials:

methoxybenzene

1-[2-(tert-butyldimethylsilyloxy)phenyl]-3-phenylprop-2-yn-1-ol

phenylacetylene

2-((tert-butyldimethylsilyl)oxy)benzaldehyde