3-amino-5-[(7-chloroquinolin-4-yl)amino]benzonitrile hydrochloride

Base Information

• Chemical Name: 3-amino-5-[(7-chloroquinolin-4-yl)amino]benzonitrile hydrochloride
• CAS No.: 1312291-13-6
• Molecular Formula: C₁₆H₁₁ClN₄*ClH
• Molecular Weight: 331.204
• Mol file: 1312291-13-6.mol

Synonyms:3-amino-5-[(7-chloroquinolin-4-yl)amino]benzonitrile hydrochloride

Chemical Property of 3-amino-5-[(7-chloroquinolin-4-yl)amino]benzonitrile hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-amino-5-[(7-chloroquinolin-4-yl)amino]benzonitrile hydrochloride

There total 2 articles about 3-amino-5-[(7-chloroquinolin-4-yl)amino]benzonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4,7-dichloroquinoline (86-98-6,1138471-54-1) + 3,5-diaminobenzonitrile (33786-93-5) → 3-amino-5-[(7-chloroquinolin-4-yl)amino]benzonitrile hydrochloride (1312291-13-6)

Guidance literature:

In ethanol; at 20 ℃; for 18h;

Reference yield:

3,5-dinitrobenzonitrile (4110-35-4) → 3-amino-5-[(7-chloroquinolin-4-yl)amino]benzonitrile hydrochloride (1312291-13-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; tin(ll) chloride / water / 2 h / 20 °C

1.2: 0 °C

2.1: ethanol / 18 h / 20 °C

With hydrogenchloride; tin(ll) chloride; In ethanol; water;

Reference yield: 44.0%

3-amino-5-[(7-chloroquinolin-4-yl)amino]benzonitrile hydrochloride (1312291-13-6) + N-chloroethylpiperidine hydrochloride (2008-75-5) → 4-[(3-amino-5-cyanophenyl)amino]-7-chloro-1-[2-(piperidin-1-yl)ethyl]quinolin-1-ium chloride (1312291-14-7)

Guidance literature:

With potassium carbonate; In acetonitrile; for 48h; Reflux;

upstream raw materials:

3,5-dinitrobenzonitrile

4,7-dichloroquinoline

3,5-diaminobenzonitrile

Downstream raw materials:

4-[(3-amino-5-cyanophenyl)amino]-7-chloro-1-[2-(piperidin-1-yl)ethyl]quinolin-1-ium chloride