methyl 3-(2-((R)-3-chloro-1-phenylpropoxy)phenylthio)propanoate

Base Information

• Chemical Name: methyl 3-(2-((R)-3-chloro-1-phenylpropoxy)phenylthio)propanoate
• CAS No.: 938435-59-7
• Molecular Formula: C₁₉H₂₁ClO₃S
• Molecular Weight: 364.893
• Mol file: 938435-59-7.mol

Synonyms:methyl 3-(2-((R)-3-chloro-1-phenylpropoxy)phenylthio)propanoate

Chemical Property of methyl 3-(2-((R)-3-chloro-1-phenylpropoxy)phenylthio)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl 3-(2-((R)-3-chloro-1-phenylpropoxy)phenylthio)propanoate

There total 2 articles about methyl 3-(2-((R)-3-chloro-1-phenylpropoxy)phenylthio)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

methyl 3-(2-hydroxyphenylsulfanyl)propanoate (938435-58-6) + 3-chloro-1-phenylpropanol (100306-34-1,125712-82-5) → methyl 3-(2-((R)-3-chloro-1-phenylpropoxy)phenylthio)propanoate (938435-59-7)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/jlcr.1128

Reference yield:

ortho-mercaptophenol (1121-24-0) → methyl 3-(2-((R)-3-chloro-1-phenylpropoxy)phenylthio)propanoate (938435-59-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / KHCO₃ / dimethylformamide / 4 h

2: 31 percent / diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C

With potassium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Michael addition / 2: Mitsunobu reaction;

DOI:10.1002/jlcr.1128

Reference yield: 30.0%

methyl 3-(2-((R)-3-chloro-1-phenylpropoxy)phenylthio)propanoate (938435-59-7) + methylamine (74-89-5) → methyl 3-(2-((R)-3-(methylamino)-1-phenylpropoxy)phenylthio)propanoate (938435-60-0)

Guidance literature:

In tetrahydrofuran; at 90 ℃; for 4h;

DOI:10.1002/jlcr.1128

upstream raw materials:

methyl 3-(2-hydroxyphenylsulfanyl)propanoate

3-chloro-1-phenylpropanol

ortho-mercaptophenol

Downstream raw materials:

methyl 3-(2-((R)-3-(methylamino)-1-phenylpropoxy)phenylthio)propanoate