(2E)-4-(dimethylamino)-N-[3-(4-{[(1S)-2-hydroxy-1-phenylethyl]amino}-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl]but-2-enamide

Base Information

Chemical Name:(2E)-4-(dimethylamino)-N-[3-(4-{[(1S)-2-hydroxy-1-phenylethyl]amino}-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl]but-2-enamide
CAS No.:1226549-49-0
Molecular Formula:C₃₂H₃₁N₅O₃
Molecular Weight:533.63
Hs Code.:

Synonyms:(2E)-4-(dimethylamino)-N-[3-(4-{[(1S)-2-hydroxy-1-phenylethyl]amino}-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl]but-2-enamide

Suppliers and Price of (2E)-4-(dimethylamino)-N-[3-(4-{[(1S)-2-hydroxy-1-phenylethyl]amino}-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl]but-2-enamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (2E)-4-(dimethylamino)-N-[3-(4-{[(1S)-2-hydroxy-1-phenylethyl]amino}-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl]but-2-enamide

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2E)-4-(dimethylamino)-N-[3-(4-{[(1S)-2-hydroxy-1-phenylethyl]amino}-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl]but-2-enamide

There total 4 articles about (2E)-4-(dimethylamino)-N-[3-(4-{[(1S)-2-hydroxy-1-phenylethyl]amino}-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl]but-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 13991-36-1
4-bromocrotonic acid

: 1226549-64-9
(2S)-2-{[5-(3-aminophenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}-2-phenylethanol

: 124-40-3
dimethyl amine

: 1226549-49-0
(2E)-4-(dimethylamino)-N-[3-(4-{[(1S)-2-hydroxy-1-phenylethyl]amino}-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl]but-2-enamide

Guidance literature:: 4-bromocrotonic acid; (2S)-2-{[5-(3-aminophenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}-2-phenylethanol; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; Inert atmosphere;

dimethyl amine; In tetrahydrofuran; water; for 8h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.9b00722

Reference yield:

: 13331-27-6
m-nitrobenzene boronic acid

: 1226549-49-0
(2E)-4-(dimethylamino)-N-[3-(4-{[(1S)-2-hydroxy-1-phenylethyl]amino}-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl]but-2-enamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / water; 1,4-dioxane / Inert atmosphere; Reflux

2.1: acetic acid; iron / water; ethanol / 2 h / 90 °C / Inert atmosphere

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

3.2: 8 h / Inert atmosphere

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; iron; sodium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; ethanol; dichloromethane; water; 1.1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.9b00722

Reference yield:

: 1073135-81-5
5-bromo-4-chloro-6-phenylfuro[2,3-d]pyrimidine

: 1226549-49-0
(2E)-4-(dimethylamino)-N-[3-(4-{[(1S)-2-hydroxy-1-phenylethyl]amino}-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl]but-2-enamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / ethanol / Reflux; Inert atmosphere

2.1: sodium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / water; 1,4-dioxane / Inert atmosphere; Reflux

3.1: acetic acid; iron / water; ethanol / 2 h / 90 °C / Inert atmosphere

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

4.2: 8 h / Inert atmosphere

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; iron; sodium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; water; 2.1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.9b00722