ethyl 4-{[(2S)-2-ethyl-7-fluoro-3-oxo-3,4-dihydroquinoxalin-1(2H)-yl]sulfonyl}phenyl carbonate

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Chemical Name:ethyl 4-{[(2S)-2-ethyl-7-fluoro-3-oxo-3,4-dihydroquinoxalin-1(2H)-yl]sulfonyl}phenyl carbonate
CAS No.:874216-84-9
Molecular Formula:C₁₉H₁₉FN₂O₆S
Molecular Weight:422.434
Hs Code.:

Synonyms:ethyl 4-{[(2S)-2-ethyl-7-fluoro-3-oxo-3,4-dihydroquinoxalin-1(2H)-yl]sulfonyl}phenyl carbonate

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Chemical Property of ethyl 4-{[(2S)-2-ethyl-7-fluoro-3-oxo-3,4-dihydroquinoxalin-1(2H)-yl]sulfonyl}phenyl carbonate

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Technology Process of ethyl 4-{[(2S)-2-ethyl-7-fluoro-3-oxo-3,4-dihydroquinoxalin-1(2H)-yl]sulfonyl}phenyl carbonate

There total 3 articles about ethyl 4-{[(2S)-2-ethyl-7-fluoro-3-oxo-3,4-dihydroquinoxalin-1(2H)-yl]sulfonyl}phenyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 178041-67-3
(3S)-3-ethyl-6-fluoro-3,4-dihydroquinoxalin-2(1H)-one

: 32978-68-0
ethyl (4-chlorosulfonyl)phenyl carbonate

: 874216-84-9
ethyl 4-{[(2S)-2-ethyl-7-fluoro-3-oxo-3,4-dihydroquinoxalin-1(2H)-yl]sulfonyl}phenyl carbonate

Guidance literature:: With pyridine; In dichloromethane; at 25 ℃; for 14h;
DOI:10.1016/j.bmc.2006.01.001

Reference yield:

: 479677-30-0
(2S)-2-[(5-fluoro-2-nitrophenyl)amino]-butanoic acid

: 874216-84-9
ethyl 4-{[(2S)-2-ethyl-7-fluoro-3-oxo-3,4-dihydroquinoxalin-1(2H)-yl]sulfonyl}phenyl carbonate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / Pd/C / ethanol / 1.5 h / 2585.74 Torr

2: 77 percent / pyridine / CH₂Cl₂ / 14 h / 25 °C

With pyridine; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2006.01.001

Reference yield:

: 446-35-5
2,4-Difluoronitrobenzene

: 874216-84-9
ethyl 4-{[(2S)-2-ethyl-7-fluoro-3-oxo-3,4-dihydroquinoxalin-1(2H)-yl]sulfonyl}phenyl carbonate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dimethylformamide / 14 h / 100 °C

2: hydrogen / Pd/C / ethanol / 1.5 h / 2585.74 Torr

3: 77 percent / pyridine / CH₂Cl₂ / 14 h / 25 °C

With pyridine; hydrogen; potassium carbonate; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.01.001