N-(4,5-Dimethyl-3-isoxazolyl)-2'-formyl-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide

Base Information

Chemical Name:N-(4,5-Dimethyl-3-isoxazolyl)-2'-formyl-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide
CAS No.:210891-12-6
Molecular Formula:C₂₁H₁₇N₃O₅S
Molecular Weight:423.449
Hs Code.:

Synonyms:N-(4,5-Dimethyl-3-isoxazolyl)-2'-formyl-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide

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Chemical Property of N-(4,5-Dimethyl-3-isoxazolyl)-2'-formyl-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide

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Technology Process of N-(4,5-Dimethyl-3-isoxazolyl)-2'-formyl-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide

There total 6 articles about N-(4,5-Dimethyl-3-isoxazolyl)-2'-formyl-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 195447-74-6
N-(4,5-dimethyl-3-isoxazolyl)-2'-formyl-N-[(2-methoxyethoxy)methyl]-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide

: 210891-12-6
N-(4,5-Dimethyl-3-isoxazolyl)-2'-formyl-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide

Guidance literature:: With hydrogenchloride; In ethanol; for 1h; Heating;
DOI:10.1021/jm020289q

Reference yield:

: 2905-25-1
o-bromobenzenesulfonyl chloride

: 210891-12-6
N-(4,5-Dimethyl-3-isoxazolyl)-2'-formyl-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 84 percent / 4-(dimethylamiono)pyridine; pyridine / 6.5 h / 40 °C

2.1: NaH / dimethylformamide / 0.5 h / 20 °C

2.2: 75 percent / dimethylformamide / 1.5 h / 20 °C

3.1: n-BuLi / tetrahydrofuran; pentane / 0.17 h / -95 °C

3.2: tetrahydrofuran; pentane / -78 - 20 °C

4.1: 3 N aq. HCl / 0.5 h

5.1: aq. Na₂CO₃; (Ph₃P)4Pd / toluene; ethanol

6.1: 92 percent / aq. HCl / ethanol / 1 h / Heating

With pyridine; hydrogenchloride; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium hydride; sodium carbonate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; pentane; 5.1: Suzuki reaction;
DOI:10.1021/jm020289q

Reference yield:

: 195447-72-4
N-(4,5-dimethyl-3-isoxazolyl)-2-bromobenzenesulfonamide

: 210891-12-6
N-(4,5-Dimethyl-3-isoxazolyl)-2'-formyl-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: 75 percent / dimethylformamide / 1.5 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; pentane / 0.17 h / -95 °C

2.2: tetrahydrofuran; pentane / -78 - 20 °C

3.1: 3 N aq. HCl / 0.5 h

4.1: aq. Na₂CO₃; (Ph₃P)4Pd / toluene; ethanol

5.1: 92 percent / aq. HCl / ethanol / 1 h / Heating

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium hydride; sodium carbonate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; pentane; 4.1: Suzuki reaction;
DOI:10.1021/jm020289q