4-[[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]amino]-2,2-dimethylbutanoic acid

Base Information

Chemical Name:4-[[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]amino]-2,2-dimethylbutanoic acid
CAS No.:210891-15-9
Molecular Formula:C₂₇H₃₀N₄O₆S
Molecular Weight:538.624
Hs Code.:

Synonyms:4-[[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]amino]-2,2-dimethylbutanoic acid

Suppliers and Price of 4-[[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]amino]-2,2-dimethylbutanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]amino]-2,2-dimethylbutanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]amino]-2,2-dimethylbutanoic acid

There total 7 articles about 4-[[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]amino]-2,2-dimethylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-amino-2,2-dimethylbutanoic acid hydrochloride

: 210891-12-6
N-(4,5-Dimethyl-3-isoxazolyl)-2'-formyl-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide

: 210891-15-9
4-[[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]amino]-2,2-dimethylbutanoic acid

Guidance literature:: 4-amino-2,2-dimethylbutanoic acid hydrochloride; N-(4,5-Dimethyl-3-isoxazolyl)-2'-formyl-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide; With sodium acetate; acetic acid; In dichloromethane; for 0.166667h; Molecular sieve;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 1.66667h;

Reference yield:

: 4-{[1-[2'-(4,5-Dimethyl-isoxazol-3-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-yl]-meth-(Z)-ylidene]-amino}-2,2-dimethyl-butyric acid

: 210891-15-9
4-[[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]amino]-2,2-dimethylbutanoic acid

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm020289q

Reference yield:

: 2905-25-1
o-bromobenzenesulfonyl chloride

: 210891-15-9
4-[[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]amino]-2,2-dimethylbutanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: 84 percent / 4-(dimethylamiono)pyridine; pyridine / 6.5 h / 40 °C

2.1: NaH / dimethylformamide / 0.5 h / 20 °C

2.2: 75 percent / dimethylformamide / 1.5 h / 20 °C

3.1: n-BuLi / tetrahydrofuran; pentane / 0.17 h / -95 °C

3.2: tetrahydrofuran; pentane / -78 - 20 °C

4.1: 3 N aq. HCl / 0.5 h

5.1: aq. Na₂CO₃; (Ph₃P)4Pd / toluene; ethanol

6.1: 92 percent / aq. HCl / ethanol / 1 h / Heating

7.1: 3A MS; AcOH; NaOAc / CH₂Cl₂ / 0.17 h

8.1: NaB(OAc)3H / CH₂Cl₂ / 2 h / 20 °C

With pyridine; hydrogenchloride; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium acetate; sodium tris(acetoxy)borohydride; sodium hydride; sodium carbonate; acetic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; pentane; 5.1: Suzuki reaction;
DOI:10.1021/jm020289q