195447-72-4

Basic information

• Product Name: 2-broMo-N-(4,5-diMethylisoxazol-3-yl)benzenesulfonaMide
• Synonyms: 2-broMo-N-(4,5-diMethylisoxazol-3-yl)benzenesulfonaMide;2-Bromo-N-(4,5-dimethyl-3-isoxazolyl)benzenesulfonamide;N-(4,5-dimethyl-3-isoxazolyl)-2-bromobenzenesulfonamide;Benzenesulfonamide, 2-bromo-N-(4,5-dimethyl-3-isoxazolyl)-
• CAS NO: 195447-72-4
• Molecular Formula: C₁₁H₁₁BrN₂O₃S
• Molecular Weight: 331.18564
• Mol File: 195447-72-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 468.832°C at 760 mmHg
• Flash Point: 237.341°C
• Appearance: /
• Density: 1.629g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: 2-broMo-N-(4,5-diMethylisoxazol-3-yl)benzenesulfonaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-broMo-N-(4,5-diMethylisoxazol-3-yl)benzenesulfonaMide(195447-72-4)
• EPA Substance Registry System: 2-broMo-N-(4,5-diMethylisoxazol-3-yl)benzenesulfonaMide(195447-72-4)

Safety Data

• Hazardous Substances Data: 195447-72-4(Hazardous Substances Data)

Usage

General Description

2-bromo-N-(4,5-dimethylisoxazol-3-yl)benzenesulfonamide is a chemical compound that has a molecular formula of C11H12BrN3O2S. It is a sulfonamide derivative that contains a bromine atom and an isoxazole moiety. 2-broMo-N-(4,5-diMethylisoxazol-3-yl)benzenesulfonaMide is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has been found to have antibacterial and antifungal properties, making it a valuable component in the development of new medications. Additionally, it has been used in research as a tool to study the structure and function of biological molecules. Overall, 2-bromo-N-(4,5-dimethylisoxazol-3-yl)benzenesulfonamide is a versatile chemical that plays a key role in various scientific and industrial applications.

InChI:InChI=1/C11H11BrN2O3S/c1-7-8(2)17-13-11(7)14-18(15,16)10-6-4-3-5-9(10)12/h3-6H,1-2H3,(H,13,14)

Upstream product

• 2905-25-1 o-bromobenzenesulfonyl chloride 
• 144-55-8 sodium hydrogencarbonate 
• 13999-39-8 4,5-dimethyl-1,2-oxazol-3-amine 
• 195447-71-3 4,5-dimethyl-3-isoxazolamine hydrochloride 

Downstream Products

• 1201936-87-9 N-(4,5-Dimethyl-3-isoxazolyl)-N-[[(2-trimethylsilyl)ethoxy]methyl]-2-bromobenzenesulfonamide 
• 210891-04-6 Edonentan 
• 195447-74-6 N-(4,5-dimethyl-3-isoxazolyl)-2'-formyl-N-[(2-methoxyethoxy)methyl]-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide 
• 210891-13-7 N-(4,5-dimethyl-3-isoxazolyl)-2'-[(methylamino)methyl]-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide 
• 210891-12-6 N-(4,5-Dimethyl-3-isoxazolyl)-2'-formyl-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide 
• 254746-77-5 [2-[[(4,5-dimethyl-3-isoxazolyl)[(2-methoxyethoxy)methyl]amino]-sulfonyl]phenyl]boronic acid 
• 195447-73-5 2-Bromo-N-(4,5-dimethyl-3-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-benzenesulfonamide 

Relevant articles and documents

Dual antagonist of angiotensin II receptor and endothelin receptor

The invention relates to dual antagonists of an angiotensin II receptor and an endothelin receptor. Specifically, the invention provides a compound represented by a formula I and a preparation method thereof. The compound can be used for treating diseases

Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2′-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4- (2-oxazolyl)[1,1′-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ETA s

We have previously disclosed the selective ETA receptor antagonist N-(3,4-dimethyl-5-isoxazolyl)-4′-(2-oxazolyl)[1,1′- biphenyl]-2-sulfonamide (1, BMS-193884) as a clinical development candidate. Additional SAR studies at the 2′-position of 1 l

SUBSTITUTED BIPHENYL SULFONAMIDE ENDOTHELIN ANTAGONISTS

Compounds of the formula STR1 inhibit the activity of endothelin.