Benzyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate

Base Information

Chemical Name:Benzyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate
CAS No.:167414-75-7
Molecular Formula:C18H23 N O5
Molecular Weight:333.384
Hs Code.:2933399090
European Community (EC) Number:675-814-8
DSSTox Substance ID:DTXSID10440155
Mol file:167414-75-7.mol

Synonyms:167414-75-7;benzyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate;4-(2-ethoxycarbonyl-acetyl)-piperidine-1-carboxylic acid benzyl ester;ETHYL 3-(N-CBZ-4-PIPERIDYL)-3-OXOPROPANOATE;3-Oxo-3-(1-Cbz-piperidin-4-yl)-propionic acid ethyl ester;ETHYL 3-(N-CBZ-PIPERIDIN-4-YL)-3-OXOPROPANOATE;MFCD04115570;4-(2-ethoxycarbonylacetyl)piperidine-1-carboxylic acid benzyl ester;ethyl 3-(1-cbz-piperidin-4-yl)-3-oxopropanoate;SCHEMBL1162669;DTXSID10440155;AMY20477;AKOS015904069;AB20257;CS-W003186;DS-15326;SY005600;FT-0769978;METHYL6-AMINO-6-DEOXY-D-MANNOPYRANOSIDE;3-oxo-3-(1-cbz-piperidin-4-yl)-propionic acidethyl ester;benzyl4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate;4-Piperidinepropanoic acid, beta-oxo-1-[(phenylmethoxy)carbonyl]-, ethyl ester

Suppliers and Price of Benzyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-(2-Ethoxycarbonyl-acetyl)-piperidine-1-carboxylicacidbenzylester
250mg
$ 55.00

Labseeker
4-(2-ETHOXYCARBONYL-ACETYL)-PIPERIDINE-1-CARBOXYLICACIDBENZYLESTER 95
10g
$ 1550.00

Crysdot
Benzyl4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate 95+%
10g
$ 339.00

Crysdot
Benzyl4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate 95+%
25g
$ 677.00

Chemenu
Benzyl4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate 95%
25g
$ 640.00

Chemenu
Benzyl4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate 95%
10g
$ 320.00

AstaTech
3-OXO-3-(1-CBZ-PIPERIDIN-4-YL)-PROPIONICACIDETHYLESTER 97%
1 / G
$ 46.00

AstaTech
3-OXO-3-(1-CBZ-PIPERIDIN-4-YL)-PROPIONICACIDETHYLESTER 97%
5 / G
$ 200.00

AstaTech
3-OXO-3-(1-CBZ-PIPERIDIN-4-YL)-PROPIONICACIDETHYLESTER 97%
25 / G
$ 700.00

American Custom Chemicals Corporation
4-(2-ETHOXYCARBONYL-ACETYL)-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER 95.00%
10G
$ 3462.41

Total 16 raw suppliers

Chemical Property of Benzyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.533
Boiling Point:461.8°Cat760mmHg
PKA:10.39±0.20(Predicted)
Flash Point:233.1°C
PSA：72.91000
Density:1.19g/cm³
LogP:2.49540
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:333.15762283
Heavy Atom Count:24
Complexity:437

Purity/Quality:

99%, ^*data from raw suppliers

4-(2-Ethoxycarbonyl-acetyl)-piperidine-1-carboxylicacidbenzylester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)CC(=O)C1CCN(CC1)C(=O)OCC2=CC=CC=C2

Technology Process of Benzyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate

There total 8 articles about Benzyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 167414-75-7
ethyl <1-(benzyloxycarbonyl)-4-piperidyl>-3-oxopropanoate

Guidance literature:

Reference yield: 87.0%

: 6148-64-7
ethyl potassium malonate

: 10314-98-4
1-benzyloxycarbonylpiperidine-4-carboxylic acid

: 167414-75-7
ethyl <1-(benzyloxycarbonyl)-4-piperidyl>-3-oxopropanoate

Guidance literature:: 1-benzyloxycarbonylpiperidine-4-carboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 4h;

ethyl potassium malonate; With dmap; magnesium chloride; In tetrahydrofuran; acetonitrile; at 20 ℃;
DOI:10.1021/acs.jmedchem.7b00304

Reference yield:

: 141-78-6
ethyl acetate

: 10314-99-5
benzyl 4-(chlorocarbonyl)piperidine-1-carboxylate

: 167414-75-7
ethyl <1-(benzyloxycarbonyl)-4-piperidyl>-3-oxopropanoate

Guidance literature:: ethyl acetate; benzyl 4-(chlorocarbonyl)piperidine-1-carboxylate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 - 0 ℃;

With hydrogenchloride; In tetrahydrofuran; hexane;