5-{5-[3-bromobenzyl]-4-methyl-1,3-oxazol-2-yl}-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole

Base Information

Chemical Name:5-{5-[3-bromobenzyl]-4-methyl-1,3-oxazol-2-yl}-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole
CAS No.:1570043-15-0
Molecular Formula:C₂₀H₁₃BrF₃N₃O₃
Molecular Weight:480.241
Hs Code.:

Synonyms:5-{5-[3-bromobenzyl]-4-methyl-1,3-oxazol-2-yl}-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole

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Chemical Property of 5-{5-[3-bromobenzyl]-4-methyl-1,3-oxazol-2-yl}-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole

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Technology Process of 5-{5-[3-bromobenzyl]-4-methyl-1,3-oxazol-2-yl}-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole

There total 10 articles about 5-{5-[3-bromobenzyl]-4-methyl-1,3-oxazol-2-yl}-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1570043-19-4
N-(4-(3-bromophenyl)-3-oxobutan-2-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole-5-carboxamide

: 1570043-15-0
5-{5-[3-bromobenzyl]-4-methyl-1,3-oxazol-2-yl}-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole

Guidance literature:: With trichlorophosphate; at 110 ℃; for 5h;

Reference yield:

: 4-(trifluoromethoxy)benzamidoxime

: 1570043-15-0
5-{5-[3-bromobenzyl]-4-methyl-1,3-oxazol-2-yl}-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / chloroform / 3 h / 0 °C / Reflux

2: water; sodium hydroxide / ethanol / 1 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 - 40 °C

4: Dess-Martin periodane / dichloromethane

5: trichlorophosphate / 5 h / 110 °C

With pyridine; water; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; In ethanol; dichloromethane; chloroform;

Reference yield:

: 1258269-03-2
ethyl 3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole-5-carboxylate

: 1570043-15-0
5-{5-[3-bromobenzyl]-4-methyl-1,3-oxazol-2-yl}-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1: water; sodium hydroxide / ethanol / 1 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 - 40 °C

3: Dess-Martin periodane / dichloromethane

4: trichlorophosphate / 5 h / 110 °C

With water; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; In ethanol; dichloromethane;