1-methyl-4-(3-((4-methyl-2-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)oxazol-5-yl)methyl)phenyl)piperazin-1-ium trifluoroacetate

Base Information

Chemical Name:1-methyl-4-(3-((4-methyl-2-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)oxazol-5-yl)methyl)phenyl)piperazin-1-ium trifluoroacetate
CAS No.:1570043-43-4
Molecular Formula:C₂HF₃O₂*C₂₅H₂₄F₃N₅O₃
Molecular Weight:613.516
Hs Code.:

Synonyms:1-methyl-4-(3-((4-methyl-2-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)oxazol-5-yl)methyl)phenyl)piperazin-1-ium trifluoroacetate

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Chemical Property of 1-methyl-4-(3-((4-methyl-2-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)oxazol-5-yl)methyl)phenyl)piperazin-1-ium trifluoroacetate

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Technology Process of 1-methyl-4-(3-((4-methyl-2-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)oxazol-5-yl)methyl)phenyl)piperazin-1-ium trifluoroacetate

There total 11 articles about 1-methyl-4-(3-((4-methyl-2-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)oxazol-5-yl)methyl)phenyl)piperazin-1-ium trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 109-01-3
1-methyl-piperazine

: 1570043-15-0
5-{5-[3-bromobenzyl]-4-methyl-1,3-oxazol-2-yl}-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole

: 76-05-1
trifluoroacetic acid

: 1570043-43-4
1-methyl-4-(3-((4-methyl-2-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)oxazol-5-yl)methyl)phenyl)piperazin-1-ium trifluoroacetate

Guidance literature:: 1-methyl-piperazine; 5-{5-[3-bromobenzyl]-4-methyl-1,3-oxazol-2-yl}-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; In 1,4-dioxane; at 120 ℃; for 1h; Inert atmosphere; Sealed tube; Microwave irradiation;

trifluoroacetic acid;

Reference yield:

: 1258269-03-2
ethyl 3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole-5-carboxylate

: 1570043-43-4
1-methyl-4-(3-((4-methyl-2-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)oxazol-5-yl)methyl)phenyl)piperazin-1-ium trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: water; sodium hydroxide / ethanol / 1 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 - 40 °C

3: Dess-Martin periodane / dichloromethane

4: trichlorophosphate / 5 h / 110 °C

5: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 1 h / 120 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; water; benzotriazol-1-ol; caesium carbonate; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; XPhos; trichlorophosphate; In 1,4-dioxane; ethanol; dichloromethane;

Reference yield:

: 1878-67-7
3-Bromophenylacetic acid

: 1570043-43-4
1-methyl-4-(3-((4-methyl-2-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)oxazol-5-yl)methyl)phenyl)piperazin-1-ium trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1: borane-THF / tetrahydrofuran / 20 °C

2: Dess-Martin periodane / dichloromethane

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 3 h / 0 °C

4: iron / ethanol; water / Reflux

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 - 40 °C

6: Dess-Martin periodane / dichloromethane

7: trichlorophosphate / 5 h / 110 °C

8: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 1 h / 120 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; borane-THF; iron; benzotriazol-1-ol; caesium carbonate; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; XPhos; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;