3-(3,4-DICHLOROPHENYL)-1-(3,4,5-TRIMETHOXYBENZOYL)-3-PYRROLIDINEETHANOL METHANSULFONATE

Base Information

• Chemical Name: 3-(3,4-DICHLOROPHENYL)-1-(3,4,5-TRIMETHOXYBENZOYL)-3-PYRROLIDINEETHANOL METHANSULFONATE
• CAS No.: 167262-42-2
• Molecular Formula: C23H27 Cl2 N O7 S
• Molecular Weight: 532.442
• Mol file: 167262-42-2.mol

Synonyms:3-Pyrrolidineethanol,3-(3,4-dichlorophenyl)-1-(3,4,5-trimethoxybenzoyl)-, methanesulfonate (ester)(9CI);1-(3,4,5-Trimethoxybenzoyl)-3-(3,4-dichlorophenyl)-3-(2-methanesulfonyloxyethyl)pyrrolidine

Chemical Property of 3-(3,4-DICHLOROPHENYL)-1-(3,4,5-TRIMETHOXYBENZOYL)-3-PYRROLIDINEETHANOL METHANSULFONATE

Chemical Property:

• PSA: 99.75000
• LogP: 5.18810

Purity/Quality:

≥98% ^*data from raw suppliers

3-(3,4-DICHLOROPHENYL)-1-(3,4,5-TRIMETHOXYBENZOYL)-3-PYRROLIDINEETHANOL METHANSULFONATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(3,4-DICHLOROPHENYL)-1-(3,4,5-TRIMETHOXYBENZOYL)-3-PYRROLIDINEETHANOL METHANSULFONATE

There total 6 articles about 3-(3,4-DICHLOROPHENYL)-1-(3,4,5-TRIMETHOXYBENZOYL)-3-PYRROLIDINEETHANOL METHANSULFONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(3,4-dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-3-(2-hydroxy-ethyl)-pyrrolidine (167262-41-1) + methanesulfonyl chloride (124-63-0) → 2-[3-(3,4-dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate (167262-42-2)

Guidance literature:

With hydrogenchloride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

3-(3,4-dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-3-(2-hydroxy-ethyl)-pyrrolidine (167262-41-1) → 2-[3-(3,4-dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate (167262-42-2)

Guidance literature:

With hydrogenchloride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

1-(4-fluoro-phenyl)-1,3,8-triaza-spiro[4.5]decane-2,4-dione hydrochloride → 2-[3-(3,4-dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate (167262-42-2)

Guidance literature:

With hydrogenchloride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; sodium chloride; In water; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

3-(3,4-dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-3-(2-hydroxy-ethyl)-pyrrolidine

methanesulfonyl chloride

1-(3,4,5-trimethoxy-benzoyl)-3-(3,4-dichloro-phenyl)-3-(2-acetoxy-ethyl)-pyrrolidine

3-(3,4-dichloro-phenyl)-3-(2-hydroxy-ethyl)-pyrrolidine

Downstream raw materials:

MDL 103392