2-((4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

Base Information

Chemical Name:2-((4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one
CAS No.:1604801-95-7
Molecular Formula:C₂₀H₁₇IN₈O
Molecular Weight:512.312
Hs Code.:

Synonyms:2-((4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

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Chemical Property of 2-((4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

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Technology Process of 2-((4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

There total 5 articles about 2-((4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1403942-00-6
2-(chloromethyl)-5-methyl-3-(o-tolyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

: 151266-23-8
4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine

: 1604801-95-7
2-((4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 1403941-99-0
3-methyl-N-(o-tolyl)-1H-pyrrole-2-carboxamide

: 1604801-95-7
2-((4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; ammonium hydroxide; ammonium chloride; sodium hypochlorite; Aliquat 336 / diethyl ether; water; tert-butyl methyl ether / 2.42 h / 0 - 20 °C

2: acetic acid / 0.5 h / 120 °C

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

With ammonium hydroxide; sodium hypochlorite; Aliquat 336; potassium carbonate; ammonium chloride; acetic acid; sodium hydroxide; In diethyl ether; tert-butyl methyl ether; water; N,N-dimethyl-formamide;

Reference yield:

: 1403941-98-9
1-amino-3-methyl-N-(o-tolyl)-1H-pyrrole-2-carboxamide

: 1604801-95-7
2-((4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / 0.5 h / 120 °C

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

With potassium carbonate; acetic acid; In N,N-dimethyl-formamide;