2-((4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

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Chemical Name:2-((4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one
CAS No.:1604800-72-7
Molecular Formula:C₂₆H₂₁FN₈O₂
Molecular Weight:496.504
Hs Code.:

Synonyms:2-((4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

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Chemical Property of 2-((4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

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Technology Process of 2-((4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

There total 6 articles about 2-((4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 871329-82-7
(3-fluoro-5-hydroxyphenyl)boronic acid

: 1604801-95-7
2-((4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

: 1604800-72-7
2-((4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,4-dioxane; water; at 100 ℃; Inert atmosphere;

Reference yield:

: 1403941-99-0
3-methyl-N-(o-tolyl)-1H-pyrrole-2-carboxamide

: 1604800-72-7
2-((4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide; ammonium hydroxide; ammonium chloride; sodium hypochlorite; Aliquat 336 / diethyl ether; water; tert-butyl methyl ether / 2.42 h / 0 - 20 °C

2: acetic acid / 0.5 h / 120 °C

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; 1,4-dioxane / 100 °C / Inert atmosphere

With ammonium hydroxide; sodium hypochlorite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; Aliquat 336; sodium carbonate; potassium carbonate; ammonium chloride; acetic acid; sodium hydroxide; In 1,4-dioxane; diethyl ether; tert-butyl methyl ether; water; N,N-dimethyl-formamide; 4: |Suzuki Coupling;

Reference yield:

: 1403941-98-9
1-amino-3-methyl-N-(o-tolyl)-1H-pyrrole-2-carboxamide

: 1604800-72-7
2-((4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 0.5 h / 120 °C

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; 1,4-dioxane / 100 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; potassium carbonate; acetic acid; In 1,4-dioxane; water; N,N-dimethyl-formamide; 3: |Suzuki Coupling;