4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-6-(1H-indol-4-yl)-1-(phenylsulfonyl)-1H-indazole

Base Information

Chemical Name:4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-6-(1H-indol-4-yl)-1-(phenylsulfonyl)-1H-indazole
CAS No.:1245464-74-7
Molecular Formula:C₂₄H₁₆ClN₅O₃S
Molecular Weight:489.942
Hs Code.:

Synonyms:4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-6-(1H-indol-4-yl)-1-(phenylsulfonyl)-1H-indazole

Suppliers and Price of 4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-6-(1H-indol-4-yl)-1-(phenylsulfonyl)-1H-indazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-6-(1H-indol-4-yl)-1-(phenylsulfonyl)-1H-indazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-6-(1H-indol-4-yl)-1-(phenylsulfonyl)-1H-indazole

There total 6 articles about 4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-6-(1H-indol-4-yl)-1-(phenylsulfonyl)-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1245464-71-4
6-(1H-indol-4-yl)-1-(phenylsulfonyl)-4-(1H-tetrazol-5-yl)-1H-indazole

: 79-04-9
chloroacetyl chloride

: 1245464-74-7
4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-6-(1H-indol-4-yl)-1-(phenylsulfonyl)-1H-indazole

Guidance literature:: In chloroform; at 100 ℃; for 2h; Microwave irradiation;
DOI:10.1021/acs.jmedchem.5b00767

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1245464-74-7
4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-6-(1H-indol-4-yl)-1-(phenylsulfonyl)-1H-indazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

1.2: 18 h / 0 - 20 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / water; 1,4-dioxane / 1 h / 60 °C

3.1: trimethylsilylazide; di(n-butyl)tin oxide / toluene / 5.75 h / 120 °C

4.1: chloroform / 2 h / 100 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; trimethylsilylazide; sodium hydride; di(n-butyl)tin oxide; In 1,4-dioxane; chloroform; water; N,N-dimethyl-formamide; toluene; mineral oil; 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.jmedchem.5b00767

Reference yield:

: 898747-00-7
6-bromo-1H-indazole-4-carbonitrile

: 1245464-74-7
4-[5-(chloromethyl)-1,3,4-oxadiazol-2-yl]-6-(1H-indol-4-yl)-1-(phenylsulfonyl)-1H-indazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

1.2: 18 h / 0 - 20 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / water; 1,4-dioxane / 1 h / 60 °C

3.1: trimethylsilylazide; di(n-butyl)tin oxide / toluene / 5.75 h / 120 °C

4.1: chloroform / 2 h / 100 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; trimethylsilylazide; sodium hydride; di(n-butyl)tin oxide; In 1,4-dioxane; chloroform; water; N,N-dimethyl-formamide; toluene; mineral oil; 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.jmedchem.5b00767