tert-butyl 1-(methoxy(methyl)amino)-1-oxooctan-2-yl(3-phenylpropyl)carbamate

Base Information

Chemical Name:tert-butyl 1-(methoxy(methyl)amino)-1-oxooctan-2-yl(3-phenylpropyl)carbamate
CAS No.:1325715-51-2
Molecular Formula:C₂₄H₄₀N₂O₄
Molecular Weight:420.593
Hs Code.:

Synonyms:tert-butyl 1-(methoxy(methyl)amino)-1-oxooctan-2-yl(3-phenylpropyl)carbamate

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Chemical Property of tert-butyl 1-(methoxy(methyl)amino)-1-oxooctan-2-yl(3-phenylpropyl)carbamate

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Technology Process of tert-butyl 1-(methoxy(methyl)amino)-1-oxooctan-2-yl(3-phenylpropyl)carbamate

There total 6 articles about tert-butyl 1-(methoxy(methyl)amino)-1-oxooctan-2-yl(3-phenylpropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1325715-29-4
2-(tert-butoxycarbonyl(3-phenylpropyl)amino)octanoic acid

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 1325715-51-2
tert-butyl 1-(methoxy(methyl)amino)-1-oxooctan-2-yl(3-phenylpropyl)carbamate

Guidance literature:: 2-(tert-butoxycarbonyl(3-phenylpropyl)amino)octanoic acid; With (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 0.25h; Inert atmosphere;

N,O-dimethylhydroxylamine*hydrochloride; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.05.123

Reference yield:

: 104-53-0
3-phenyl-propionaldehyde

: 1325715-51-2
tert-butyl 1-(methoxy(methyl)amino)-1-oxooctan-2-yl(3-phenylpropyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide monohydrate / methanol / 0.33 h / 20 °C

1.2: 1 h

2.1: sodium tetrahydroborate / methanol / 0.5 h

3.1: tetra(n-butyl)ammonium hydroxide / acetonitrile / 0.5 h / 20 °C

3.2: 18 h / 20 °C

4.1: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

4.2: 18 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; lithium hydroxide monohydrate; tetra(n-butyl)ammonium hydroxide; triethylamine; In methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2011.05.123

Reference yield:

: C₁₇H₂₅NO₂

: 1325715-51-2
tert-butyl 1-(methoxy(methyl)amino)-1-oxooctan-2-yl(3-phenylpropyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / methanol / 0.5 h

2.1: tetra(n-butyl)ammonium hydroxide / acetonitrile / 0.5 h / 20 °C

2.2: 18 h / 20 °C

3.1: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

3.2: 18 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; tetra(n-butyl)ammonium hydroxide; triethylamine; In methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2011.05.123