17β-tert-Butoxy-1,3-dimethoxy-7α-(phenylsulfonyl)-1,3,5(10),9(11)-oestratetraen

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Chemical Name:17β-tert-Butoxy-1,3-dimethoxy-7α-(phenylsulfonyl)-1,3,5(10),9(11)-oestratetraen
CAS No.:75019-21-5
Molecular Formula:C₃₀H₃₈O₅S
Molecular Weight:510.695
Hs Code.:

Synonyms:17β-tert-Butoxy-1,3-dimethoxy-7α-(phenylsulfonyl)-1,3,5(10),9(11)-oestratetraen

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Chemical Property of 17β-tert-Butoxy-1,3-dimethoxy-7α-(phenylsulfonyl)-1,3,5(10),9(11)-oestratetraen

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Technology Process of 17β-tert-Butoxy-1,3-dimethoxy-7α-(phenylsulfonyl)-1,3,5(10),9(11)-oestratetraen

There total 6 articles about 17β-tert-Butoxy-1,3-dimethoxy-7α-(phenylsulfonyl)-1,3,5(10),9(11)-oestratetraen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 82079-97-8
(1S,3aS,4S,7aS)-1-tert-Butoxy-4-<(1R)-2-(3,5-dimethoxyphenyl)-1-(phenylsulfonyl)ethyl>-5,5-(ethylendioxy)-2,3,3a,4,5,6,7,7a-octahydro-7a-methyl-1H-inden

: 75019-21-5
17β-tert-Butoxy-1,3-dimethoxy-7α-(phenylsulfonyl)-1,3,5(10),9(11)-oestratetraen

Guidance literature:: With sulfuric acid; In acetone; at -20 ℃; for 0.166667h;
DOI:10.1002/jlac.198219820306

Reference yield:

: 41878-38-0
(1S,7aS)-1-tert-butoxy-7a-methyl-1,2,3,6,7,7a-hexahydro-5H-inden-5-one

: 75019-21-5
17β-tert-Butoxy-1,3-dimethoxy-7α-(phenylsulfonyl)-1,3,5(10),9(11)-oestratetraen

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / tetramethylethylenediamine / acetic acid / 60 h / 35 °C

2: 70 percent / H₂, 1N HCl / 10percent Pd/C / ethanol

3: 75 percent / conc. H₂SO₄, HC(OC₂H₅)3 / dioxane / 24 h / Ambient temperature

4: 33 percent / LDA / tetrahydrofuran / 12 h / -20 °C

5: 33 percent / conc. H₂SO₄ / acetone / 0.17 h / -20 °C

With hydrogenchloride; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; hydrogen; orthoformic acid triethyl ester; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; acetic acid; acetone;
DOI:10.1002/jlac.198219820306

Reference yield:

: 51168-78-6
(1S,7aS)-1-tert-Butoxy-1,2,3,6,7,7a-hexahydro-7a-methyl-4-<(phenylsulfonyl)methyl>-5H-inden-5-on

: 75019-21-5
17β-tert-Butoxy-1,3-dimethoxy-7α-(phenylsulfonyl)-1,3,5(10),9(11)-oestratetraen

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / H₂, 1N HCl / 10percent Pd/C / ethanol

2: 75 percent / conc. H₂SO₄, HC(OC₂H₅)3 / dioxane / 24 h / Ambient temperature

3: 33 percent / LDA / tetrahydrofuran / 12 h / -20 °C

4: 33 percent / conc. H₂SO₄ / acetone / 0.17 h / -20 °C

With hydrogenchloride; sulfuric acid; hydrogen; orthoformic acid triethyl ester; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; acetone;
DOI:10.1002/jlac.198219820306