N2-[(dimethylamino)methylene]-3'-O-[(N,N-diisopropylamino)-2-cyanoethoxyphosphinyl]-5'-O-(4,4'-dimethoxytrityl)-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-guanine

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Chemical Name:N2-[(dimethylamino)methylene]-3'-O-[(N,N-diisopropylamino)-2-cyanoethoxyphosphinyl]-5'-O-(4,4'-dimethoxytrityl)-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-guanine
CAS No.:1391913-24-8
Molecular Formula:C₄₃H₅₂FN₈O₇P
Molecular Weight:842.907
Hs Code.:

N2-[(dimethylamino)methylene]-3'-O-[(N,N-diisopropylamino)-2-cyanoethoxyphosphinyl]-5'-O-(4,4'-dimethoxytrityl)-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-guanine

Synonyms:N2-[(dimethylamino)methylene]-3'-O-[(N,N-diisopropylamino)-2-cyanoethoxyphosphinyl]-5'-O-(4,4'-dimethoxytrityl)-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-guanine

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Chemical Property of N2-[(dimethylamino)methylene]-3'-O-[(N,N-diisopropylamino)-2-cyanoethoxyphosphinyl]-5'-O-(4,4'-dimethoxytrityl)-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-guanine

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Technology Process of N2-[(dimethylamino)methylene]-3'-O-[(N,N-diisopropylamino)-2-cyanoethoxyphosphinyl]-5'-O-(4,4'-dimethoxytrityl)-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-guanine

There total 3 articles about N2-[(dimethylamino)methylene]-3'-O-[(N,N-diisopropylamino)-2-cyanoethoxyphosphinyl]-5'-O-(4,4'-dimethoxytrityl)-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1391913-22-6
N2-[(dimethylamino)methylene]-5'-O-(4,4'-dimethoxytrityl)-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-guanine

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 1391913-24-8
N2-[(dimethylamino)methylene]-3'-O-[(N,N-diisopropylamino)-2-cyanoethoxyphosphinyl]-5'-O-(4,4'-dimethoxytrityl)-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-guanine

Guidance literature:: With 1H-tetrazole; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1002/anie.201109004

Reference yield:

: 103884-98-6
9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-guanine

: 1391913-24-8
N2-[(dimethylamino)methylene]-3'-O-[(N,N-diisopropylamino)-2-cyanoethoxyphosphinyl]-5'-O-(4,4'-dimethoxytrityl)-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-guanine

Guidance literature:: Multi-step reaction with 3 steps

1: 6 h / 70 °C

2: pyridine / 6 h / 20 °C

3: 1H-tetrazole / dichloromethane / 4 h / 20 °C

With pyridine; 1H-tetrazole; In dichloromethane;
DOI:10.1002/anie.201109004

Reference yield:

: 1391913-21-5
N2-[(dimethylamino)methylene]-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-guanine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1391913-24-8
N2-[(dimethylamino)methylene]-3'-O-[(N,N-diisopropylamino)-2-cyanoethoxyphosphinyl]-5'-O-(4,4'-dimethoxytrityl)-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-guanine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 6 h / 20 °C

2: 1H-tetrazole / dichloromethane / 4 h / 20 °C

With pyridine; 1H-tetrazole; In dichloromethane;
DOI:10.1002/anie.201109004