(R)-methyl 4-(4-chlorophenyl)-2-methoxycarbonylamino-4-oxobutanoate

Base Information

• Chemical Name: (R)-methyl 4-(4-chlorophenyl)-2-methoxycarbonylamino-4-oxobutanoate
• CAS No.: 358349-88-9
• Molecular Formula: C₁₃H₁₄ClNO₅
• Molecular Weight: 299.711
• Mol file: 358349-88-9.mol

Synonyms:(R)-methyl 4-(4-chlorophenyl)-2-methoxycarbonylamino-4-oxobutanoate

Chemical Property of (R)-methyl 4-(4-chlorophenyl)-2-methoxycarbonylamino-4-oxobutanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (R)-methyl 4-(4-chlorophenyl)-2-methoxycarbonylamino-4-oxobutanoate

There total 1 articles about (R)-methyl 4-(4-chlorophenyl)-2-methoxycarbonylamino-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

methanol (67-56-1) + (2R)-4-(4-chlorophenyl)-2-(methoxycarbonylamino)-4-oxobutanoic acid (166942-26-3) → (R)-methyl 4-(4-chlorophenyl)-2-methoxycarbonylamino-4-oxobutanoate (358349-88-9)

Guidance literature:

With thionyl chloride;

DOI:10.1016/S0040-4020(01)00420-3

Reference yield: 87.0%

(R)-methyl 4-(4-chlorophenyl)-2-methoxycarbonylamino-4-oxobutanoate (358349-88-9) → methyl (R)-4-(4-chlorophenyl)-2-(methoxycarbonylamino)-butanoate

Guidance literature:

With triethylsilane; trimethylsilyl trifluoromethanesulfonate; titanium tetrachloride; In dichloromethane; at 20 ℃; for 20h;

DOI:10.1016/S0040-4020(01)00420-3

Reference yield: 71.0%

(R)-methyl 4-(4-chlorophenyl)-2-methoxycarbonylamino-4-oxobutanoate (358349-88-9) → (R)-2-methoxycarbonylamino-4-(4-chlorophenyl)butyl methyl ether

Guidance literature:

With triethylsilane; trimethylsilyl trifluoromethanesulfonate; titanium tetrachloride; In dichloromethane; at 20 ℃; for 20h;

DOI:10.1016/S0040-4020(01)00420-3

upstream raw materials:

methanol

(2R)-4-(4-chlorophenyl)-2-(methoxycarbonylamino)-4-oxobutanoic acid