PMC-34

Base Information

• Chemical Name: PMC-34
• CAS No.: 1363339-68-7
• Molecular Formula: C₁₄H₂₃N₂O₄*K
• Molecular Weight: 322.446
• Mol file: 1363339-68-7.mol

Synonyms:PMC-34

Chemical Property of PMC-34

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of PMC-34

There total 6 articles about PMC-34 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

oseltamivir (196618-13-0) → PMC-34 (1363339-68-7)

Guidance literature:

With potassium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 4h;

DOI:10.1016/j.bmc.2012.01.026

Reference yield:

ethyl-(3R,4S,5R)-5-azido-4-hydroxy-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate (204254-98-8) → PMC-34 (1363339-68-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: trimethylphosphane / tetrahydrofuran; acetonitrile / 2.17 h / 20 °C / Inert atmosphere

2.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 70 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: 4-methyl-morpholine / dichloromethane / 0 - 20 °C

4.1: dichloromethane; toluene / 2 h / 20 °C

5.1: hydrogenchloride; water / dichloromethane; toluene / 4 h / 20 °C

5.2: pH 10

6.1: potassium hydroxide / 1,4-dioxane; water / 4 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; sodium azide; water; ammonium chloride; potassium hydroxide; trimethylphosphane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1016/j.bmc.2012.01.026

Reference yield:

C19H35N2O4P (1362750-80-8) → PMC-34 (1363339-68-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; water / dichloromethane; toluene / 4 h / 20 °C

1.2: pH 10

2.1: potassium hydroxide / 1,4-dioxane; water / 4 h / 20 °C

With hydrogenchloride; water; potassium hydroxide; In 1,4-dioxane; dichloromethane; water; toluene;

DOI:10.1016/j.bmc.2012.01.026

upstream raw materials:

C₁₉H₃₅N₂O₄P

oseltamivir

ethyl-(3R,4R,5S)-4-amino-5-azido-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate

oseltamivir

Refernces