1-[4-(8-methoxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]cyclo-butanamine

Base Information

Chemical Name:1-[4-(8-methoxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]cyclo-butanamine
CAS No.:1402608-08-5
Molecular Formula:C₂₃H₂₂N₄O
Molecular Weight:370.454
Hs Code.:

Synonyms:1-[4-(8-methoxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]cyclo-butanamine

Suppliers and Price of 1-[4-(8-methoxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]cyclo-butanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[4-(8-methoxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]cyclo-butanamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[4-(8-methoxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]cyclo-butanamine

There total 5 articles about 1-[4-(8-methoxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]cyclo-butanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1402609-00-0
tert-butyl {1-[4-(8-methoxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)-phenyl]cyclobutyl}carbamate

: 1402608-08-5
1-[4-(8-methoxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]cyclo-butanamine

Guidance literature:: tert-butyl {1-[4-(8-methoxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)-phenyl]cyclobutyl}carbamate; With hydrogenchloride; In 1,4-dioxane; methanol; dichloromethane; at 20 ℃; for 60h;

With sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water; pH=> 7; Cooling with ice;

Reference yield:

: 1032349-98-6
tert-butyl 1-(4-(2-phenylacetyl)phenyl)cyclobutylcarbamate

: 1402608-08-5
1-[4-(8-methoxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]cyclo-butanamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridinium hydrobromide perbromide / tetrahydrofuran / 0.5 h / 0 °C

2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 8 h / Reflux

3.1: methanol / 4 h / 20 °C / Cooling with ice

4.1: sodium formate / 5%-palladium/activated carbon / N,N-dimethyl-formamide; water / 3 h / 80 °C

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 60 h / 20 °C

5.2: pH > 7 / Cooling with ice

With hydrogenchloride; sodium formate; pyridinium hydrobromide perbromide; N-ethyl-N,N-diisopropylamine; 5%-palladium/activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1402608-89-2
tert-butyl (1-{4-[3-phenyl-6-bromo-8-methoxyimidazo[1,2-b]pyridazin-2-yl]-phenyl}cyclobutyl)carbamate

: 1402608-08-5
1-[4-(8-methoxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)phenyl]cyclo-butanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium formate / 5%-palladium/activated carbon / N,N-dimethyl-formamide; water / 3 h / 80 °C

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 60 h / 20 °C

2.2: pH > 7 / Cooling with ice

With hydrogenchloride; sodium formate; 5%-palladium/activated carbon; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;