(2S,1''S,2''R,1''''R)-1''-[3'''-({1''''-[(tert-butoxy)carbonyl]-2''''-(p-methoxyphenyl)ethyl}carbamoyl)allyl]-2''-methyl-4''-phenylbut-3''-enyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}propionyl)oxy]-4-methylpentanoate

Base Information

Chemical Name:(2S,1''S,2''R,1''''R)-1''-[3'''-({1''''-[(tert-butoxy)carbonyl]-2''''-(p-methoxyphenyl)ethyl}carbamoyl)allyl]-2''-methyl-4''-phenylbut-3''-enyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}propionyl)oxy]-4-methylpentanoate
CAS No.:728944-93-2
Molecular Formula:C₄₃H₆₀N₂O₁₀
Molecular Weight:764.957
Hs Code.:

(2S,1''S,2''R,1''''R)-1''-[3'''-({1''''-[(tert-butoxy)carbonyl]-2''''-(p-methoxyphenyl)ethyl}carbamoyl)allyl]-2''-methyl-4''-phenylbut-3''-enyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}propionyl)oxy]-4-methylpentanoate

Synonyms:(2S,1''S,2''R,1''''R)-1''-[3'''-({1''''-[(tert-butoxy)carbonyl]-2''''-(p-methoxyphenyl)ethyl}carbamoyl)allyl]-2''-methyl-4''-phenylbut-3''-enyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}propionyl)oxy]-4-methylpentanoate

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Chemical Property of (2S,1''S,2''R,1''''R)-1''-[3'''-({1''''-[(tert-butoxy)carbonyl]-2''''-(p-methoxyphenyl)ethyl}carbamoyl)allyl]-2''-methyl-4''-phenylbut-3''-enyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}propionyl)oxy]-4-methylpentanoate

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Technology Process of (2S,1''S,2''R,1''''R)-1''-[3'''-({1''''-[(tert-butoxy)carbonyl]-2''''-(p-methoxyphenyl)ethyl}carbamoyl)allyl]-2''-methyl-4''-phenylbut-3''-enyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}propionyl)oxy]-4-methylpentanoate

There total 19 articles about (2S,1''S,2''R,1''''R)-1''-[3'''-({1''''-[(tert-butoxy)carbonyl]-2''''-(p-methoxyphenyl)ethyl}carbamoyl)allyl]-2''-methyl-4''-phenylbut-3''-enyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}propionyl)oxy]-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 281191-02-4
(2R,2'E,5'S,6'R,7'E)-tert-butyl 2-[(5'-hydroxy-6'-methyl-8'-phenylocta-2',7'-dienoyl)amino]-3-(4-methoxyphenyl)propionate

: 326473-59-0
(2S)-2-[(3'-{[(tert-butoxy)carbonyl]amino}propionyl)oxy]-4-methylpentanoic acid

: 728944-93-2
(2S,1''S,2''R,1''''R)-1''-[3'''-({1''''-[(tert-butoxy)carbonyl]-2''''-(p-methoxyphenyl)ethyl}carbamoyl)allyl]-2''-methyl-4''-phenylbut-3''-enyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}propionyl)oxy]-4-methylpentanoate

Guidance literature:: (2S)-2-[(3'-{[(tert-butoxy)carbonyl]amino}propionyl)oxy]-4-methylpentanoic acid; With 2,4,6-trichlorobenzoyl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 23 ℃; for 2h;

(2R,2'E,5'S,6'R,7'E)-tert-butyl 2-[(5'-hydroxy-6'-methyl-8'-phenylocta-2',7'-dienoyl)amino]-3-(4-methoxyphenyl)propionate; With dmap; In benzene; at 23 ℃; for 1h;
DOI:10.1002/ejoc.200300814

Reference yield:

: 13748-90-8,498-36-2
(S)-2-hydroxyl-3,3-dimethylbutyric acid

: 728944-93-2
(2S,1''S,2''R,1''''R)-1''-[3'''-({1''''-[(tert-butoxy)carbonyl]-2''''-(p-methoxyphenyl)ethyl}carbamoyl)allyl]-2''-methyl-4''-phenylbut-3''-enyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}propionyl)oxy]-4-methylpentanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: Cs₂CO₃ / methanol; H₂O / 30 h / 23 °C

1.2: 100 percent / dimethylformamide / 12 h / 20 °C

2.1: 91 percent / DCC; DMAP / CH₂Cl₂ / 12 h / 23 °C

3.1: 97 percent / H₂ / 5 percent Pd/C / ethyl acetate / 1 h / 23 °C

4.1: iPr₂NEt; 2,4,6-Cl₃C₆H₂COCl / tetrahydrofuran / 2 h / 23 °C

4.2: 80 percent / DMAP / benzene / 1 h / 23 °C

With dmap; 2,4,6-trichlorobenzoyl chloride; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;
DOI:10.1002/ejoc.200300814

Reference yield:

: 37755-48-9,40298-04-2
benzyl (2S)-2-hydroxy-4-methylpentanoate

: 728944-93-2
(2S,1''S,2''R,1''''R)-1''-[3'''-({1''''-[(tert-butoxy)carbonyl]-2''''-(p-methoxyphenyl)ethyl}carbamoyl)allyl]-2''-methyl-4''-phenylbut-3''-enyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}propionyl)oxy]-4-methylpentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 91 percent / DCC; DMAP / CH₂Cl₂ / 12 h / 23 °C

2.1: 97 percent / H₂ / 5 percent Pd/C / ethyl acetate / 1 h / 23 °C

3.1: iPr₂NEt; 2,4,6-Cl₃C₆H₂COCl / tetrahydrofuran / 2 h / 23 °C

3.2: 80 percent / DMAP / benzene / 1 h / 23 °C

With dmap; 2,4,6-trichlorobenzoyl chloride; hydrogen; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1002/ejoc.200300814