N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N'-(cyclohexylmethyl)-N-(2,2-dimethylpropyl)succinamide

Base Information

Chemical Name:N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N'-(cyclohexylmethyl)-N-(2,2-dimethylpropyl)succinamide
CAS No.:1292849-77-4
Molecular Formula:C₂₉H₃₈Cl₂N₂O₃
Molecular Weight:533.538
Hs Code.:

Synonyms:N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N'-(cyclohexylmethyl)-N-(2,2-dimethylpropyl)succinamide

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Chemical Property of N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N'-(cyclohexylmethyl)-N-(2,2-dimethylpropyl)succinamide

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Technology Process of N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N'-(cyclohexylmethyl)-N-(2,2-dimethylpropyl)succinamide

There total 6 articles about N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N'-(cyclohexylmethyl)-N-(2,2-dimethylpropyl)succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1292849-66-1
4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoic acid

: 3218-02-8
cyclohexylmethylamine

: 1292849-77-4
N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N'-(cyclohexylmethyl)-N-(2,2-dimethylpropyl)succinamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1016/j.bmc.2011.01.065

Reference yield:

: 1292849-65-0
methyl 4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoate

: 1292849-77-4
N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N'-(cyclohexylmethyl)-N-(2,2-dimethylpropyl)succinamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol; water / 12 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2011.01.065

Reference yield:

: 74067-45-1
2-amino-5-chloro-α-(2'-chlorophenyl)benzyl alcohol

: 1292849-77-4
N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}-N'-(cyclohexylmethyl)-N-(2,2-dimethylpropyl)succinamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate; acetic acid

2: sodium hydrogencarbonate / dichloromethane / 2 h / 20 °C / Cooling with ice

3: potassium carbonate / methanol; water / 12 h / 20 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

With sodium tetrahydroborate; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2011.01.065