methyl 4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoate

Base Information

Chemical Name:methyl 4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoate
CAS No.:1292849-65-0
Molecular Formula:C₂₃H₂₇Cl₂NO₄
Molecular Weight:452.378
Hs Code.:

Synonyms:methyl 4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoate

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Chemical Property of methyl 4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoate

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Technology Process of methyl 4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoate

There total 4 articles about methyl 4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 152906-79-1
{5-chloro-2-[(2,2-dimethylpropyl)amino]phenyl}(2-chlorophenyl)methanol

: 1490-25-1
succinic acid monomethylester chloride

: 1292849-65-0
methyl 4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoate

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 2h; Cooling with ice;
DOI:10.1016/j.bmc.2011.01.065

Reference yield:

: 74067-45-1
2-amino-5-chloro-α-(2'-chlorophenyl)benzyl alcohol

: 1292849-65-0
methyl 4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate; acetic acid

2: sodium hydrogencarbonate / dichloromethane / 2 h / 20 °C / Cooling with ice

With sodium tetrahydroborate; sodium hydrogencarbonate; acetic acid; In dichloromethane;
DOI:10.1016/j.bmc.2011.01.065

Reference yield:

: 630-19-3
pivalaldehyde

: 1292849-65-0
methyl 4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate; acetic acid

2: sodium hydrogencarbonate / dichloromethane / 2 h / 20 °C / Cooling with ice

With sodium tetrahydroborate; sodium hydrogencarbonate; acetic acid; In dichloromethane;
DOI:10.1016/j.bmc.2011.01.065