N-((S)-1-((R)-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)propan-2-yl)-3-phenylpropiolamide 2,2,2-trifluoroacetate

Base Information

Chemical Name:N-((S)-1-((R)-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)propan-2-yl)-3-phenylpropiolamide 2,2,2-trifluoroacetate
CAS No.:1262536-61-7
Molecular Formula:C₂HF₃O₂*C₂₆H₂₈FN₃O₂
Molecular Weight:547.55
Hs Code.:

Synonyms:N-((S)-1-((R)-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)propan-2-yl)-3-phenylpropiolamide 2,2,2-trifluoroacetate

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Chemical Property of N-((S)-1-((R)-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)propan-2-yl)-3-phenylpropiolamide 2,2,2-trifluoroacetate

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Technology Process of N-((S)-1-((R)-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)propan-2-yl)-3-phenylpropiolamide 2,2,2-trifluoroacetate

There total 5 articles about N-((S)-1-((R)-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)propan-2-yl)-3-phenylpropiolamide 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-8-((S)-2-aminopropyl)-4-(4-fluorophenyl)-2,8-diazaspiro[4.5]decan-1-one bis(2,2,2-trifluoroacetate)

: 637-44-5
phenylpropyolic acid

: 1262536-61-7
N-((S)-1-((R)-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)propan-2-yl)-3-phenylpropiolamide 2,2,2-trifluoroacetate

Guidance literature:: phenylpropyolic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; for 0.25h; Inert atmosphere;

(R)-8-((S)-2-aminopropyl)-4-(4-fluorophenyl)-2,8-diazaspiro[4.5]decan-1-one bis(2,2,2-trifluoroacetate); In dichloromethane; Inert atmosphere;

Reference yield:

: 857681-22-2
rac-4-(4-fluoro-phenyl)-2,8-diaza-spiro[4.5]decan-1-one hydrochloride

: 1262536-61-7
N-((S)-1-((R)-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)propan-2-yl)-3-phenylpropiolamide 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide / ethyl acetate; water / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 20 °C / Inert atmosphere

3.1: Chiraltech OJ column / isopropyl alcohol; hexanes / 1.08 h / Resolution of racemate

4.1: trifluoroacetic acid / dichloromethane / Inert atmosphere

4.2: Inert atmosphere

5.1: MP-sodium triacetoxyborohydride resin / dichloromethane; tetrahydrofuran / Inert atmosphere

6.1: dichloromethane / 20 °C / Inert atmosphere

7.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.25 h / Inert atmosphere

7.2: Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; hexanes; dichloromethane; water; ethyl acetate; isopropyl alcohol;

Reference yield:

: 857680-66-1
rac-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester

: 1262536-61-7
N-((S)-1-((R)-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)propan-2-yl)-3-phenylpropiolamide 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: Chiraltech OJ column / isopropyl alcohol; hexanes / 1.08 h / Resolution of racemate

2.1: trifluoroacetic acid / dichloromethane / Inert atmosphere

2.2: Inert atmosphere

3.1: MP-sodium triacetoxyborohydride resin / dichloromethane; tetrahydrofuran / Inert atmosphere

4.1: dichloromethane / 20 °C / Inert atmosphere

5.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.25 h / Inert atmosphere

5.2: Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; hexanes; dichloromethane; isopropyl alcohol;