1H-pyrrolo[2,3-c]pyridin-7-amine

Base Information

• Chemical Name: 1H-pyrrolo[2,3-c]pyridin-7-amine
• CAS No.: 165669-36-3
• Molecular Formula: C₇H₇N₃
• Molecular Weight: 133.153
• Hs Code.: 2933990090
• European Community (EC) Number: 837-990-6
• DSSTox Substance ID: DTXSID50597879
• Wikidata: Q82493538
• Mol file: 165669-36-3.mol

Synonyms:1H-pyrrolo[2,3-c]pyridin-7-amine;165669-36-3;1H-Pyrrolo[2,3-c]pyridin-7-amine(9CI);7-amino-1H-pyrrolo[2,3-c]pyridine;7-AMINO-6-AZAINDOLE;7-Amino-6-azaindole;SCHEMBL401223;AMY9963;DTXSID50597879;SBSKAJKJHGZYCY-UHFFFAOYSA-N;MFCD09834951;AKOS006328096;AB52926;AS-49518;DB-003568;CS-0060713;EN300-115674;I11178;A810655

Chemical Property of 1H-pyrrolo[2,3-c]pyridin-7-amine

Chemical Property:

• Vapor Pressure: 3.04E-06mmHg at 25°C
• Refractive Index: 1.78
• Boiling Point: 388.5 °C at 760 mmHg
• PKA: 15.34±0.40(Predicted)
• Flash Point: 217.1 °C
• PSA: 54.70000
• Density: 1.367 g/cm³
• LogP: 1.72630
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 133.063997236
• Heavy Atom Count: 10
• Complexity: 126

Purity/Quality:

97% ^*data from raw suppliers

1H-pyrrolo[2,3-c]pyridin-7-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CNC2=C1C=CN=C2N

Technology Process of 1H-pyrrolo[2,3-c]pyridin-7-amine

There total 7 articles about 1H-pyrrolo[2,3-c]pyridin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

7-chloro-1H-pyrrolo[2,3-c]pyridine (357263-41-3) → 1H-pyrrolo[2,3-c]pyridine-7-amine (165669-36-3)

Guidance literature:

With ammonium hydroxide; copper; copper(l) chloride; at 120 ℃; for 17h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.jmedchem.8b01642

Reference yield:

2-bromo-3-nitropyridine (19755-53-4) → 1H-pyrrolo[2,3-c]pyridine-7-amine (165669-36-3)

Guidance literature:

With ammonia; copper; copper(I) chloride;

Reference yield:

2-bromo-3-nitropyridine (19755-53-4) + aqueous concentrated ammonia + 7-bromo-1H-pyrrolo[2,3-c]pyridine (165669-35-2) + copper (12775-96-1,15158-11-9,15721-63-8,16941-75-6,17493-86-6,19498-52-3,20499-83-6,20499-84-7,20499-85-8,20499-86-9,20573-10-8,20573-11-9,21595-51-7,21595-52-8,22206-52-6,26445-28-3,28959-95-7,37362-93-9,39417-05-5,54603-16-6,54603-23-5,54603-32-6,54603-40-6,54603-48-4,54603-81-5,54603-89-3,56316-56-4,95985-91-4,122297-32-9,7440-50-8) → 1H-pyrrolo[2,3-c]pyridine-7-amine (165669-36-3)

Guidance literature:

copper(I) chloride;

upstream raw materials:

2-bromo-3-nitropyridine

7-bromo-1H-pyrrolo[2,3-c]pyridine

copper

2-Chloro-3-nitropyridine

Downstream raw materials:

7-bromo-1H-pyrrolo[2,3-c]pyridine