7-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE

Base Information

• Chemical Name: 7-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE
• CAS No.: 357263-41-3
• Molecular Formula: C7H5ClN2
• Molecular Weight: 152.583
• Hs Code.: 2933990090
• Mol file: 357263-41-3.mol

Synonyms:7-Chloro-6-azaindole;7-Chloro-1H-pyrrolo[2,3-c]pyridine;7-chloro-1H-pyrrolo[2,3-c]pyridine;1H-Pyrrolo[2,3-c]pyridine, 7-chloro-;7-Chloro-1H-pyrrolo[2,3-c]pyridine;

Chemical Property of 7-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 123-124 °C
• Refractive Index: 1.703
• Boiling Point: 335.794 °C at 760 mmHg
• PKA: 13.08±0.40(Predicted)
• Flash Point: 187.228 °C
• PSA: 28.68000
• Density: 1.425 g/cm³
• LogP: 2.21630
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Chloro-1H-pyrrolo[2,3-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-41
• Safety Statements: 26-36/37/39-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE

There total 10 articles about 7-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-(2-chloro-5-nitro-4-pyridyl)-N,N-dimethyletheneamine (142078-44-2) → 7-chloro-1H-pyrrolo[2,3-c]pyridine (357263-41-3)

Guidance literature:

With sodium acetate; iron; acetic acid; In ethanol; water; for 2h; Reflux;

DOI:10.3390/molecules27010247

Reference yield: 56.0%

1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one (259684-36-1) → 7-chloro-1H-pyrrolo[2,3-c]pyridine (357263-41-3)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 2.5h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.8b01642

Reference yield: 42.0%

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) + vinyl magnesium bromide (1826-67-1) → 7-chloro-1H-pyrrolo[2,3-c]pyridine (357263-41-3)

Guidance literature:

In tetrahydrofuran; at -50 - -40 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm401899x

upstream raw materials:

2-Chloro-3-nitropyridine

vinyl magnesium bromide

vinylmagnesium chloride

4-Methyl-3-nitro-2-pyridone

Downstream raw materials:

N-(3-{1-[7-chloro-1-(2-methoxy-ethyl)-1H-pyrrolo[2,3-c]pyridine-3-carbonyl]-piperidin-4-yl}-4-fluoro-benzyl)-2,2,2-trifluoro-acetamide

2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-pyrrolo[2,3-c]pyridine-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide

[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxy-ethyl)-7-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl]-methanone

Refernces

• 1、 -. "HETEROCYCLIC PAD4 INHIBITORS". Page/Page column 187. . Retrieved 2021/08/20.
• 2、 -. "Medicine composition for treating diabetes and nephropathy and preparation method of composition". Paragraph 0009. . Retrieved 2018/10/02.