1-[3-(bromomethyl)-4-(4-methoxyphenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-2-yl]ethan-1-one

Base Information

Chemical Name:1-[3-(bromomethyl)-4-(4-methoxyphenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-2-yl]ethan-1-one
CAS No.:1003867-44-4
Molecular Formula:C₁₆H₂₀BrNO₃
Molecular Weight:354.244
Hs Code.:

Synonyms:1-[3-(bromomethyl)-4-(4-methoxyphenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-2-yl]ethan-1-one

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Chemical Property of 1-[3-(bromomethyl)-4-(4-methoxyphenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-2-yl]ethan-1-one

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Technology Process of 1-[3-(bromomethyl)-4-(4-methoxyphenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-2-yl]ethan-1-one

There total 2 articles about 1-[3-(bromomethyl)-4-(4-methoxyphenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-2-yl]ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 910916-54-0
3-(bromomethyl)-4-(4-methoxyphenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazine

: 506-96-7
Acetyl bromide

: 1003867-44-4
1-[3-(bromomethyl)-4-(4-methoxyphenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-2-yl]ethan-1-one

Guidance literature:: With acetic anhydride; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1055/s-2007-990857

Reference yield: 19.0%

: 929878-88-6
4-(4-methoxyphenyl)-3,6,6-trimethyl-5,6-dihydro-4H-1,2-oxazine 2-oxide

: 506-96-7
Acetyl bromide

: 108-24-7
acetic anhydride

: 1003867-44-4
1-[3-(bromomethyl)-4-(4-methoxyphenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-2-yl]ethan-1-one

Guidance literature:: In dichloromethane; at 20 ℃; for 24h;
DOI:10.1002/ejoc.201900131

Reference yield: 88.0%

: 1003867-44-4
1-[3-(bromomethyl)-4-(4-methoxyphenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-2-yl]ethan-1-one

: 108-59-8
malonic acid dimethyl ester

: 1619976-58-7
dimethyl 2-{[2-acetyl-4-(4-methoxyphenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-3-yl]methyl}malonate

Guidance literature:: malonic acid dimethyl ester; With potassium tert-butylate; In N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h; Inert atmosphere;

1-[3-(bromomethyl)-4-(4-methoxyphenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-2-yl]ethan-1-one; In N,N-dimethyl-formamide; at 0 - 40 ℃; for 3h; Inert atmosphere;
DOI:10.1002/ejoc.201900131