4-(5-chloro-2-methoxy-phenyl)-pyridine-2,6-dicarboxylic acid diethyl ester

Base Information

Chemical Name:4-(5-chloro-2-methoxy-phenyl)-pyridine-2,6-dicarboxylic acid diethyl ester
CAS No.:767334-80-5
Molecular Formula:C₁₈H₁₈ClNO₅
Molecular Weight:363.798
Hs Code.:

Synonyms:4-(5-chloro-2-methoxy-phenyl)-pyridine-2,6-dicarboxylic acid diethyl ester

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Chemical Property of 4-(5-chloro-2-methoxy-phenyl)-pyridine-2,6-dicarboxylic acid diethyl ester

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Technology Process of 4-(5-chloro-2-methoxy-phenyl)-pyridine-2,6-dicarboxylic acid diethyl ester

There total 3 articles about 4-(5-chloro-2-methoxy-phenyl)-pyridine-2,6-dicarboxylic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 53389-01-8
diethyl 4-chloropyridine-2,6-dicarboxylate

: 89694-48-4
5-chloro-2-methoxyphenyl boronic acid

: 767334-80-5
4-(5-chloro-2-methoxy-phenyl)-pyridine-2,6-dicarboxylic acid diethyl ester

Guidance literature:: With sodium carbonate; palladium diacetate; triphenylphosphine; In 1,2-dimethoxyethane; water; at 80 ℃; for 3h;

Reference yield:

: 71022-75-8
4-chloropyridine-2,6-dicarbonyl dichloride

: 767334-80-5
4-(5-chloro-2-methoxy-phenyl)-pyridine-2,6-dicarboxylic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine

2: Pd(OAc)2; PPh₃; Na₂CO₃ / 1,2-dimethoxy-ethane; H₂O

With pyridine; palladium diacetate; sodium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; water; 2: Suzuki reaction;
DOI:10.1016/j.bmcl.2005.07.055

Reference yield:

: 499-51-4
Chelidamic acid

: 767334-80-5
4-(5-chloro-2-methoxy-phenyl)-pyridine-2,6-dicarboxylic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / Heating

2: pyridine

3: Pd(OAc)2; PPh₃; Na₂CO₃ / 1,2-dimethoxy-ethane; H₂O

With pyridine; palladium diacetate; oxalyl dichloride; sodium carbonate; N,N-dimethyl-formamide; triphenylphosphine; In 1,2-dimethoxyethane; dichloromethane; water; 3: Suzuki reaction;
DOI:10.1016/j.bmcl.2005.07.055