N₁-[2-(biphenyl-4-yloxy)ethanoyl]-N₄-(4-fluorophenyl)-thiosemicarbazide

Base Information

• Chemical Name: N₁-[2-(biphenyl-4-yloxy)ethanoyl]-N₄-(4-fluorophenyl)-thiosemicarbazide
• CAS No.: 905231-34-7
• Molecular Formula: C₂₁H₁₈FN₃O₂S
• Molecular Weight: 395.457

Synonyms:N₁-[2-(biphenyl-4-yloxy)ethanoyl]-N₄-(4-fluorophenyl)-thiosemicarbazide

Chemical Property of N₁-[2-(biphenyl-4-yloxy)ethanoyl]-N₄-(4-fluorophenyl)-thiosemicarbazide

Chemical Property:

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Technology Process of N₁-[2-(biphenyl-4-yloxy)ethanoyl]-N₄-(4-fluorophenyl)-thiosemicarbazide

There total 2 articles about N₁-[2-(biphenyl-4-yloxy)ethanoyl]-N₄-(4-fluorophenyl)-thiosemicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-(biphenyl-4-yloxy)acetic acid hydrazide (84161-08-0) + 4-fluorophenyl isothiocyanate (1544-68-9) → N1-[2-(biphenyl-4-yloxy)ethanoyl]-N4-(4-fluorophenyl)-thiosemicarbazide (905231-34-7)

Guidance literature:

In ethanol; Reflux;

DOI:10.1002/ardp.201100128

Reference yield:

4-Phenylphenol (92-69-3) → N1-[2-(biphenyl-4-yloxy)ethanoyl]-N4-(4-fluorophenyl)-thiosemicarbazide (905231-34-7)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone / Reflux

2: hydrazine hydrate / 4 h / Reflux

3: ethanol / Reflux

With potassium carbonate; hydrazine hydrate; In ethanol; acetone;

DOI:10.1002/ardp.201100128

Reference yield: 76.0%

N1-[2-(biphenyl-4-yloxy)ethanoyl]-N4-(4-fluorophenyl)-thiosemicarbazide (905231-34-7) → 5-[(biphenyl-4-yloxy)methyl]4-(4-fluorophenyl)-3-mercapto-(4H)-1,2,4-triazole (1104067-91-5)

Guidance literature:

With triethylamine; In ethanol; Reflux;

DOI:10.1002/ardp.201100128

upstream raw materials:

2-(biphenyl-4-yloxy)acetic acid hydrazide

4-fluorophenyl isothiocyanate

4-Phenylphenol

Downstream raw materials:

5-[(biphenyl-4-yloxy)methyl]-2-(4-fluorophenylamino)-1,3,4-oxadiazole

5-[(biphenyl-4-yloxy)methyl]4-(4-fluorophenyl)-3-mercapto-(4H)-1,2,4-triazole

5-[(biphenyl-4-yloxy)methyl]-2-(4-fluorophenylamino)-1,3,4-thiadiazole

2-{5-[(4-biphenyloxy)methyl]-4-(4-fluorophenyl)-4H-1,2,4-triazol-3-ylthio}-1-(4-bromophenyl)ethanone

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