2-(3-(4-bromophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-yl)-4-(6-chlorocoumarin-3-yl)thiazole

Base Information

• Chemical Name: 2-(3-(4-bromophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-yl)-4-(6-chlorocoumarin-3-yl)thiazole
• CAS No.: 1430228-89-9
• Molecular Formula: C₂₂H₁₂BrClF₃N₃O₃S
• Molecular Weight: 570.774
• Mol file: 1430228-89-9.mol

Synonyms:2-(3-(4-bromophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-yl)-4-(6-chlorocoumarin-3-yl)thiazole

Chemical Property of 2-(3-(4-bromophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-yl)-4-(6-chlorocoumarin-3-yl)thiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-(4-bromophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-yl)-4-(6-chlorocoumarin-3-yl)thiazole

There total 4 articles about 2-(3-(4-bromophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-yl)-4-(6-chlorocoumarin-3-yl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-(2-bromoacetyl)-6-chloro-2H-chromen-2-one (106577-99-5) + 3-(4-bromo-phenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydro-pyrazole-1-carbothioic acid amide (219986-60-4) → 2-(3-(4-bromophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-yl)-4-(6-chlorocoumarin-3-yl)thiazole (1430228-89-9)

Guidance literature:

In ethanol; for 6h; Reflux;

DOI:10.1016/j.ejmech.2012.11.046

Reference yield:

4-chlorosalicylaldehyde (2420-26-0) → 2-(3-(4-bromophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-yl)-4-(6-chlorocoumarin-3-yl)thiazole (1430228-89-9)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine / 0 - 5 °C

2: bromine / chloroform

3: ethanol / 6 h / Reflux

With piperidine; bromine; In ethanol; chloroform; 3: |Hantzsch Thiazole Synthesis;

DOI:10.1016/j.ejmech.2012.11.046

Reference yield:

3-acetyl-6-chlorocoumarin (53653-66-0) → 2-(3-(4-bromophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-yl)-4-(6-chlorocoumarin-3-yl)thiazole (1430228-89-9)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine / chloroform

2: ethanol / 6 h / Reflux

With bromine; In ethanol; chloroform; 2: |Hantzsch Thiazole Synthesis;

DOI:10.1016/j.ejmech.2012.11.046

upstream raw materials:

4,4,4-trifluoro-1-(4-bromophenyl)butane-1,3-dione

3-(2-bromoacetyl)-6-chloro-2H-chromen-2-one

3-(4-bromo-phenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydro-pyrazole-1-carbothioic acid amide

3-acetyl-6-chlorocoumarin