2-[N-(2-chloroethyl)-2,4-dinitro-6-({[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino}carbonyl)anilino]ethyl methanesulfonate

Base Information

• Chemical Name: 2-[N-(2-chloroethyl)-2,4-dinitro-6-({[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino}carbonyl)anilino]ethyl methanesulfonate
• CAS No.: 944088-84-0
• Molecular Formula: C₁₉H₂₇ClN₄O₁₀S
• Molecular Weight: 538.963

Synonyms:2-[N-(2-chloroethyl)-2,4-dinitro-6-({[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino}carbonyl)anilino]ethyl methanesulfonate

Chemical Property of 2-[N-(2-chloroethyl)-2,4-dinitro-6-({[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino}carbonyl)anilino]ethyl methanesulfonate

Chemical Property:

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Technology Process of 2-[N-(2-chloroethyl)-2,4-dinitro-6-({[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino}carbonyl)anilino]ethyl methanesulfonate

There total 2 articles about 2-[N-(2-chloroethyl)-2,4-dinitro-6-({[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino}carbonyl)anilino]ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-[(2-chloroethyl)(2-hydroxyethyl)amino]-3,5-dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide (944088-69-1) + methanesulfonyl chloride (124-63-0) → 2-[N-(2-chloroethyl)-2,4-dinitro-6-({[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino}carbonyl)anilino]ethyl methanesulfonate (944088-84-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h;

DOI:10.1016/j.tet.2007.04.044

Reference yield:

2-chloro-3,5-dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide (680199-30-8) → 2-[N-(2-chloroethyl)-2,4-dinitro-6-({[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino}carbonyl)anilino]ethyl methanesulfonate (944088-84-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / Et₃N / CH₂Cl₂ / 0.17 h / 0 °C

With triethylamine; In dichloromethane;

DOI:10.1016/j.tet.2007.04.044

Reference yield:

2-[N-(2-chloroethyl)-2,4-dinitro-6-({[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]amino}carbonyl)anilino]ethyl methanesulfonate (944088-84-0) → 2-[(2-chloroethyl)-2-[[(2-hydroxyethyl)amino]carbonyl]-4,6-dinitroanilino]ethyl methanesulfonate (851627-43-5)

Guidance literature:

With methanol; methanesulfonic acid; at 20 ℃; for 2h; Product distribution / selectivity;

upstream raw materials:

2-[(2-chloroethyl)(2-hydroxyethyl)amino]-3,5-dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide

methanesulfonyl chloride

2-chloro-3,5-dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide

Downstream raw materials:

2-[(2-chloroethyl)-2-[[(2-hydroxyethyl)amino]carbonyl]-4,6-dinitroanilino]ethyl methanesulfonate

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