(3R,4R)-4-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-3-methyldihydrofuran-2(3H)-one

Base Information

Chemical Name:(3R,4R)-4-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-3-methyldihydrofuran-2(3H)-one
CAS No.:1141365-40-3
Molecular Formula:C₂₃H₃₀O₃Si
Molecular Weight:382.575
Hs Code.:

Synonyms:(3R,4R)-4-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-3-methyldihydrofuran-2(3H)-one

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Chemical Property of (3R,4R)-4-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-3-methyldihydrofuran-2(3H)-one

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Technology Process of (3R,4R)-4-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-3-methyldihydrofuran-2(3H)-one

There total 2 articles about (3R,4R)-4-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-3-methyldihydrofuran-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1355178-55-0
C₇H₁₂O₃

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1141365-40-3
(3R,4R)-4-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-3-methyldihydrofuran-2(3H)-one

: 1338472-03-9
(3S,4R)-4-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-3-methyldihydrofuran-2(3H)-one

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 15h; Inert atmosphere;
DOI:10.1021/ol202425e

Reference yield:

: C₇H₁₂O₃

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1141365-40-3
(3R,4R)-4-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-3-methyldihydrofuran-2(3H)-one

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 25 ℃; for 12h; Inert atmosphere;
DOI:10.1002/anie.200805488

Reference yield: 78.0%

: 67-56-1
methanol

: 540-88-5
acetic acid tert-butyl ester

: 1141365-40-3
(3R,4R)-4-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-3-methyldihydrofuran-2(3H)-one

: 1141365-41-4
C₃₀H₄₄O₅Si

Guidance literature:: acetic acid tert-butyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1.08333h; Inert atmosphere;

(3R,4R)-4-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-3-methyldihydrofuran-2(3H)-one; In tetrahydrofuran; at -78 - 25 ℃; Inert atmosphere;

methanol; at 25 ℃; for 12h;
DOI:10.1002/anie.200805488