trans-tert-butyl {4-[2-methoxy-5-(2-methyl-pyridin-4-yl)-benzylamino]-cyclohexyl}-methyl-carbamate

Base Information

• Chemical Name: trans-tert-butyl {4-[2-methoxy-5-(2-methyl-pyridin-4-yl)-benzylamino]-cyclohexyl}-methyl-carbamate
• CAS No.: 945998-86-7
• Molecular Formula: C₂₆H₃₇N₃O₃
• Molecular Weight: 439.598
• Mol file: 945998-86-7.mol

Synonyms:trans-tert-butyl {4-[2-methoxy-5-(2-methyl-pyridin-4-yl)-benzylamino]-cyclohexyl}-methyl-carbamate

Chemical Property of trans-tert-butyl {4-[2-methoxy-5-(2-methyl-pyridin-4-yl)-benzylamino]-cyclohexyl}-methyl-carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-tert-butyl {4-[2-methoxy-5-(2-methyl-pyridin-4-yl)-benzylamino]-cyclohexyl}-methyl-carbamate

There total 6 articles about trans-tert-butyl {4-[2-methoxy-5-(2-methyl-pyridin-4-yl)-benzylamino]-cyclohexyl}-methyl-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

2-methoxy-5-(2-methyl-pyridin-4-yl)-benzaldehyde (945998-84-5) + trans-N-methyl-N-tert-butoxycarbonyl-1,4-diaminocyclohexane (566172-79-0) → trans-tert-butyl {4-[2-methoxy-5-(2-methyl-pyridin-4-yl)-benzylamino]-cyclohexyl}-methyl-carbamate (945998-86-7)

Guidance literature:

2-methoxy-5-(2-methyl-pyridin-4-yl)-benzaldehyde; trans-N-methyl-N-tert-butoxycarbonyl-1,4-diaminocyclohexane; With acetic acid; In tetrahydrofuran; toluene; at 20 ℃; for 2h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; toluene; for 1h;

With hydrogenchloride; potassium carbonate; more than 3 stages;

Reference yield:

4-chIoro-2-methylpyridine (3678-63-5) + 3-formyl-4-methoxyphenylboronic acid (121124-97-8) → trans-tert-butyl {4-[2-methoxy-5-(2-methyl-pyridin-4-yl)-benzylamino]-cyclohexyl}-methyl-carbamate (945998-86-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 16.25 h / 20 - 85 °C

1.2: 20 °C

1.3: pH 10

2.1: acetic acid / tetrahydrofuran; toluene / 2 h / 20 °C

2.2: 1 h

With potassium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; toluene;

Reference yield:

(1r,4r)-N1-methylcyclohexane-1,4-diamine (15803-59-5,1932261-28-3,38362-02-6) → trans-tert-butyl {4-[2-methoxy-5-(2-methyl-pyridin-4-yl)-benzylamino]-cyclohexyl}-methyl-carbamate (945998-86-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: benzaldehyde / toluene / 6 h / Heating / reflux

1.2: 3.25 h / 20 °C

2.1: acetic acid / tetrahydrofuran; toluene / 2 h / 20 °C

2.2: 1 h

With benzaldehyde; acetic acid; In tetrahydrofuran; toluene;

upstream raw materials:

2-methoxy-5-(2-methyl-pyridin-4-yl)-benzaldehyde

trans-N-methyl-N-tert-butoxycarbonyl-1,4-diaminocyclohexane

4-chIoro-2-methylpyridine

3-formyl-4-methoxyphenylboronic acid