N-(4-chlorobenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine hydrochloride

Base Information

Chemical Name:N-(4-chlorobenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine hydrochloride
CAS No.:1322645-85-1
Molecular Formula:C₂₆H₃₈ClN₃O₄S₂*ClH
Molecular Weight:592.651
Hs Code.:

Synonyms:N-(4-chlorobenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-chlorobenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine hydrochloride

Chemical Property:

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Technology Process of N-(4-chlorobenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine hydrochloride

There total 8 articles about N-(4-chlorobenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1322645-08-8
N-(4-chlorobenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine

: 1322645-85-1
N-(4-chlorobenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; dichloromethane; water; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jm2002603

Reference yield:

: C₁₇H₂₆N₂O₂S

: 1322645-85-1
N-(4-chlorobenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / ethanol / 12 h / 20 °C / Inert atmosphere

2.1: sodium carbonate / acetonitrile / 48 h / Inert atmosphere; Reflux

3.1: hydrazine hydrate / ethanol / 3 h / Inert atmosphere; Reflux

3.2: 1.5 h / Inert atmosphere

4.1: sodium carbonate; sodium chloride / dichloromethane; water / 24 h / 20 °C / Inert atmosphere

5.1: hydrogenchloride / methanol; dichloromethane; water / 4 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; sodium carbonate; hydrazine hydrate; sodium chloride; In methanol; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm2002603

Reference yield:

: 1322644-99-4
N-(p-toluenesulfonamidopropyl)cyclohexylmethylamine

: 1322645-85-1
N-(4-chlorobenzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / acetonitrile / 48 h / Inert atmosphere; Reflux

2.1: hydrazine hydrate / ethanol / 3 h / Inert atmosphere; Reflux

2.2: 1.5 h / Inert atmosphere

3.1: sodium carbonate; sodium chloride / dichloromethane; water / 24 h / 20 °C / Inert atmosphere

4.1: hydrogenchloride / methanol; dichloromethane; water / 4 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium carbonate; hydrazine hydrate; sodium chloride; In methanol; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm2002603